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Ashok Aspatwar

Tampere UniversityIN
ORCID0000-0002-6938-7835
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26

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Citations
2,036

via OpenAlex

Publications
91

About

Ashok Aspatwar is a researcher at Tampere University. He has focused on understanding the molecular mechanisms of Mycobacterium, particularly pH regulation and latency, in relation to tuberculosis pathogenesis and drug development. With over 91 publications spanning from 1970 to 2026, his work explores the intersections of machine learning, biological networks, and systems biology approaches in understanding the complexities of disease.

Research areas

  • Biology
  • Medicine
  • Chemistry
  • Enzyme
  • Biochemistry

Publications (91)

Sorted by most cited.

  1. Elucidating molecular mechanism and chemical space of chalcones through biological networks and machine learning approaches

    Computational and Structural Biotechnology Journal1970journal article

    View DOI
    11 cites

  2. Integrated machine learning-driven QSAR modelling and systems biology approach for the identification of potential SARS-CoV-2 3CLpro inhibitors

    SAR and QSAR in Environmental Research1970journal article

    View DOI
    1 cites

  3. When the host is not healthy: Rethinking tuberculosis drug targets in comorbid conditions

    Tuberculosis2026journal article

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    0 cites

  4. Combating Drug Resistance in Mycobacterium Tuberculosis : A Combinatorial in Silico and Experimental Modeling Approach Toward Novel ATP Synthase Inhibitor Discovery

    Bioinformatics and Biology Insights2026journal article

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    0 cites

  5. Exploring the Potential of Coumarins against the Flavoenzyme DprE1 forAnti-TB Activity: Insights from Molecular Docking, In silico Druglikeness,ADMET, MD Simulations, MMGBSA, and DFT Studies

    2026

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    0 cites

  6. Integrated in silico and in vitro screening approaches for the discovery of small-molecule inhibitors of β-carbonic anhydrases

    Expert Opinion on Drug Discovery2026journal article

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    0 cites

  7. RNAi therapeutics targeting Japanese encephalitis virus

    Virology2026journal article

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    0 cites

  8. Tuberculosis Vaccines

    Vaccines2025other

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    0 cites

  9. Exploring the functional food potential of Zea mays using machine learning–based QSAR and network biology to identify anti-diabetic and anti-inflammatory phytochemicals

    International Journal of Food Science and Technology2025journal article

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    0 cites

  10. Impact of diabetes mellitus on tuberculosis prevention, diagnosis, and treatment from an immunologic perspective

    Exploration2024journal article

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    0 cites

  11. Physiological modeling of the metaverse of the Mycobacterium tuberculosis β-CA inhibition mechanism

    Computers in Biology and Medicine2024journal article

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    0 cites

  12. Integrated Graph-Based Models Unveil Carbonic Anhydrase VIII, X, XI Expression in Cancer and Neurological Diseases

    2024preprint

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    0 cites

  13. A multidimensional network-based approach to elucidate the molecular mechanism underlying tuberculosis and HIV coinfection

    2024preprint

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    0 cites

  14. RETRACTED: Herbal-based nanosystems: A novel drug-delivery treatment procedure against neurodegenerative disorders

    2024preprint

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    0 cites

  15. RETRACTED: Nanoparticles of Herbal Extracts in Treatment of Neurodegenerative Disorders

    2024preprint

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    0 cites

  16. A data and knowledge-driven integrated modeling approach to organ-specific Tuberculosis subtype discovery: A one health paradigm

    2024preprint

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    0 cites

  17. RETRACTED: Pharmacokinetics-Pharmacodynamics (PK-PD) Modeling: A translational path to brain-targeted drug delivery

    2024preprint

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    0 cites

  18. A multi-dimensional systems biology approach to elucidate the mechanism of action of Mycobacterium tuberculosis γ-carbonic anhydrase inhibitors

    2024preprint

    View DOI
    0 cites

  19. Revisiting Bacille Calmette-Guérin revaccination strategies

    Clinical and Translational Discovery2024journal article

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    0 cites

  20. Elucidating Molecular Mechanism and Chemical Space of Chalcones through Knowledge Graph and Machine Learning: A Combined Bio-Cheminformatic Pipeline

    2024preprint

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    0 cites

  21. Evolutionary trajectories of beta-lactamase NDM and DLST cluster in Pseudomonas aeruginosa : finding the putative ancestor

    Pathogens and Global Health2024journal article

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    0 cites

  22. Exploring nature's hidden treasure

    Heliyon2024journal article

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    0 cites

  23. Sulphonamide inhibition studies of the β-carbonic anhydrase GsaCAβ present in the salmon platyhelminth parasite Gyrodactylus salaris

    Journal of Enzyme Inhibition and Medicinal Chemistry2023journal article

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    0 cites

  24. A novel facile synthesis of metal nitride@metal oxide (BN/Gd2O3) nanocomposite and their antibacterial and anticancer activities

    Scientific Reports2023journal article

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    0 cites

  25. SARS-CoV-2 variants and COVID-19 vaccines: Current challenges and future strategies

    International Reviews of Immunology2023journal article

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    0 cites

  26. Navigating bioactivity space in anti-tubercular drug discovery through the deployment of advanced machine learning models and cheminformatics tools

    Frontiers in Pharmacology2023journal article

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    0 cites

  27. Inhibition Studies on Human and Mycobacterial Carbonic Anhydrases with <i>N</i>-((4-Sulfamoylphenyl)carbamothioyl) Amides

    Molecules2023journal article

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    0 cites

  28. Medicinal Plants as Therapeutic Alternatives to Combat <i>Mycobacterium tuberculosis</i>: A Comprehensive Review

    Antibiotics2023journal article

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    0 cites

  29. Editorial

    Frontiers in Immunology2023other

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    0 cites

  30. Mitochondrial carbonic anhydrase VA and VB: properties and roles in health and disease

    The Journal of Physiology2023journal article

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    0 cites

  31. Cloning, purification, kinetic and anion inhibition studies of a recombinant β-carbonic anhydrase from the Atlantic salmon parasite platyhelminth Gyrodactylus salaris

    Journal of Enzyme Inhibition and Medicinal Chemistry2022journal article

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    0 cites

  32. Roles of Carbonic Anhydrases and Carbonic Anhydrase Related Proteins in Zebrafish

    International Journal of Molecular Sciences2022journal article

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    0 cites

  33. Roles of Carbonic Anhydrases and Carbonic Anhydrases Related Proteins in Zebrafish

    2022working paper

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    0 cites

  34. Tuberculosis vaccine BCG: the magical effect of the old vaccine in the fight against the COVID-19 pandemic

    International Reviews of Immunology2022journal article

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    0 cites

  35. Immunogenic properties of empty pcDNA3 plasmid against zoonotic cutaneous leishmaniasis in mice

    PLoS ONE2022journal article

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    0 cites

  36. COVID-19 pandemic

    Expert Review of Vaccines2021journal article

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    0 cites

  37. Genetic diversity analysis of Blastocystis subtypes and their distribution among the domestic animals and pigeons in northwest of Iran

    Infection, Genetics and Evolution2020journal article

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    0 cites

  38. Carbonic anhydrases from pathogens: protozoan CAs and related inhibitors as potential antiprotozoal agents

    Carbonic Anhydrases Biochemistry and Pharmacology of an Evergreen Pharmaceutical Target2019book chapter

    0 cites

  39. Carbonic Anhydrase Inhibitors as Novel Drugs against Mycobacterial β-Carbonic Anhydrases: An Update on In Vitro and In Vivo Studies

    Molecules2018journal article

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    0 cites

  40. An Update on the Metabolic Roles of Carbonic Anhydrases in a Model Alga <em>Chlamydomonas reinhardtii</em>

    2018working paper

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    0 cites

  41. Zebrafish as a Model Organism for the Development of Drugs for Skin Cancer.

    Int. J. Mol. Sci.2017journal article

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    0 cites

  42. Carbonic Anhydrase XIII

    Carbonic anhydrase XIII. In, Carbonic Anhydrases as Biocatalysts: From Theory to Medical and Industrial Applications.2015book chapter

    0 cites

  43. Computational and Experimental Characterization of Mycobacterium marinum β-Carbonic Anhydrase Inhibitors

    Bioinformatics and Biology Insights1970journal article

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    0 cites

  44. Prognostic implications of TIMP1 gene expression in colon Adenocarcinoma

    Network Modeling Analysis in Health Informatics and Bioinformatics1970journal article

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    0 cites

  45. Community series in research advances of tuberculosis vaccine and its implication on COVID-19

    Frontiers in Immunology1970journal issue

    0 cites

  46. Editorial

    Frontiers in Immunology1970other

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    0 cites

  47. Making sense of carbonic anhydrase function in zebrafish using antisense morpholinos

    Molecular Genetics and Genomics1970journal article

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    0 cites

  48. Advanced nutraceutical approaches to Parkinson's disease

    Nutritional Neuroscience1970journal article

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    0 cites

  49. A Predictive ML-QSAR Approach for Targeting GSK-3β in Alzheimer's Disease

    Advanced theory and simulations1970journal article

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    0 cites

  50. Gut microbiota and tuberculosis

    iMeta1970journal article

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    0 cites

  51. Physiological role of bicarbonate in microbes

    Virulence1970journal article

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    0 cites

  52. Special Issue: Research Progress of New Tuberculosis Vaccines and Vaccine Design

    Vaccines1970journal issue

    0 cites

  53. Tuberculosis vaccines and therapeutic drug

    Molecular Biomedicine1970journal article

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    0 cites

  54. A cheminformatics and network pharmacology approach to elucidate the mechanism of action of Mycobacterium tuberculosis γ-carbonic anhydrase inhibitors

    Frontiers in Pharmacology1970journal article

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    0 cites

  55. Comparative study of volatile oil constituents, anti-microbial properties, and antibiofilm activities in Eucalyptus camaldulensis and Eucalyptus globulus

    Journal of Essential Oil-Bearing Plants1970journal article

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    0 cites

  56. Mycobacterial β-carbonic anhydrases

    The Enzymes1970book chapter

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    0 cites

  57. Brucellosis

    Annals of Medicine1970journal article

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    0 cites

  58. Dosentit - yliopiston merkittävä voimavara

    Tampereen dosenttiyhdistyksen julkaisuja1970book

    0 cites

  59. PD-1 and PD-L1

    Frontiers in Immunology1970journal article

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    0 cites

  60. Research Topic: Research Advances of Tuberculosis Vaccine and its Implication on COVID-19

    Frontiers in Immunology1970journal issue

    0 cites

  61. Carbonic anhydrases in metazoan model organisms

    Physiological Reviews1970journal article

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    0 cites

  62. Targeting Carbonic Anhydrase Isozymes in the Treatment of Neurological Disorders

    The Carbonic Anhydrases: Current and Emerging Therapeutic Targets1970book chapter

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    0 cites

  63. Bionomics and phylo-molecular analysis of Leishmania species isolated from human lesions using ITS1 genes in north-east of Iran

    Journal of Parasitic Diseases1970journal article

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    0 cites

  64. Cytokine profile and nitric oxide levels in peritoneal macrophages of BALB/c mice exposed to the fucose-mannose ligand of Leishmania infantum combined with glycyrrhizin

    Parasites and Vectors1970journal article

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    0 cites

  65. Design, synthesis, in vitro inhibition and toxicological evaluation of human carbonic anhydrases I, II and IX inhibitors in 5-nitroimidazole series

    Journal of Enzyme Inhibition and Medicinal Chemistry1970journal article

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    0 cites

  66. Hypoxia-activated prodrug derivatives of carbonic anhydrase inhibitors in benzenesulfonamide series: Synthesis and biological evaluation

    Molecules1970journal article

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    0 cites

  67. In vitro inhibition of Mycobacterium tuberculosis β-carbonic anhydrase 3 with Mono- and dithiocarbamates and evaluation of their toxicity using zebrafish developing embryos

    Journal of Enzyme Inhibition and Medicinal Chemistry1970journal article

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    0 cites

  68. Toxicity evaluation of sulfamides and coumarins that efficiently inhibit human carbonic anhydrases

    Journal of Enzyme Inhibition and Medicinal Chemistry1970journal article

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    0 cites

  69. Mycobacterium tuberculosis β-carbonic anhydrases: Novel targets for developing antituberculosis drugs

    International Journal of Molecular Sciences1970journal article

    View DOI
    0 cites

  70. Carbonic anhydrases from pathogens: Protozoan CAs and related inhibitors as potential antiprotozoal agents

    Carbonic Anhydrases: Biochemistry and Pharmacology of an Evergreen Pharmaceutical Target1970book chapter

    View DOI
    0 cites

  71. Efficacy of Novel CA IX Inhibitors in Biological Models

    Carbonic Anhydrase as Drug Target : Thermodynamics and Structure of Inhibitor Binding1970book chapter

    View DOI
    0 cites

  72. Catalytically inactive carbonic anhydrase-related proteins enhance transport of lactate by MCT1

    FEBS Open Bio1970journal article

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    0 cites

  73. Rapid evaluation of toxicity of chemical compounds using zebrafish embryos

    Journal of Visualized Experiments1970journal article

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    0 cites

  74. An update on the metabolic roles of carbonic anhydrases in the model alga chlamydomonas reinhardtii

    Metabolites1970journal article

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    0 cites

  75. Carbonic anhydrase related protein expression in astrocytomas and oligodendroglial tumors

    BMC Cancer1970journal article

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    0 cites

  76. Nitroimidazole-based inhibitors DTP338 and DTP348 are safe for zebrafish embryos and efficiently inhibit the activity of human CA IX in Xenopus oocytes

    Journal of Enzyme Inhibition and Medicinal Chemistry1970journal article

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    0 cites

  77. An update on anticancer drug development and delivery targeting carbonic anhydrase IX

    PeerJ1970journal article

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    0 cites

  78. Fluorinated benzenesulfonamide anticancer inhibitors of carbonic anhydrase IX exhibit lower toxic effects on zebrafish embryonic development than ethoxzolamide

    Drug and Chemical Toxicology1970journal article

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    0 cites

  79. Identification and characterization of a novel zebrafish (Danio rerio) pentraxin-carbonic anhydrase

    PeerJ1970journal article

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    0 cites

  80. Zebrafish as a model organism for the development of drugs for skin cancer

    International Journal of Molecular Sciences1970journal article

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    0 cites

  81. β-CA-specific inhibitor dithiocarbamate Fc14–584B: a novel antimycobacterial agent with potential to treat drug-resistant tuberculosis

    Journal of Enzyme Inhibition and Medicinal Chemistry1970journal article

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    0 cites

  82. Carbonic Anhydrase XIII

    Carbonic Anhydrases as Biocatalysts: From Theory to Medical and Industrial Applications1970book chapter

    View DOI
    0 cites

  83. Inactivation of Ca10a and Ca10b genes leads to abnormal embryonic development and alters movement pattern in zebrafish

    PLoS ONE1970journal article

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    0 cites

  84. Carbonic anhydrase related proteins: Molecular biology and evolution

    Sub-Cellular Biochemistry1970journal article

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    0 cites

  85. Distribution and Function of Carbonic Anhydrase Related Proteins (CARPs) VIII, X and XI

    Acta Universitatis Tamperensis1970dissertation thesis

    0 cites

  86. An update on carbonic anhydrase-related proteins VIII, X and XI

    Journal of Enzyme Inhibition and Medicinal Chemistry1970journal article

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    0 cites

  87. Abnormal cerebellar development and ataxia in carp VIII morphant zebrafish

    Human Molecular Genetics1970journal article

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    0 cites

  88. Analysis of evolution of carbonic anhydrases IV and XV reveals a rich history of gene duplications and a new group of isozymes

    Bioorganic and Medicinal Chemistry1970journal article

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    0 cites

  89. Carbonic anhydrase related protein VIII and its role in neurodegeneration and cancer

    Current Pharmaceutical Design1970journal article

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    0 cites

  90. Phylogeny and expression of carbonic anhydrase-related proteins

    BMC Molecular Biology1970journal article

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    0 cites

  91. Evolutionary analysis of WD40 super family proteins involved in spindle checkpoint and RNA export: molecular evolution of spindle checkpoint

    Bioinformation1970journal article

    0 cites