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Ashok Aspatwar

Tampere UniversityIN
ORCID0000-0002-6938-7835
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26

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Citations
2,079

via OpenAlex

Publications
126

About

Ashok Aspatwar is a researcher at Tampere University. He has focused on understanding the molecular mechanisms of Mycobacterium, particularly pH regulation and latency, in relation to tuberculosis pathogenesis and drug development. With over 91 publications spanning from 1970 to 2026, his work explores the intersections of machine learning, biological networks, and systems biology approaches in understanding the complexities of disease.

Research areas

  • Biology
  • Medicine
  • Chemistry
  • Enzyme
  • Biochemistry

Publications (126)

Sorted by most cited.

  1. Brucellosis

    Annals of Medicine1970journal article

    View DOI
    258 cites

  2. PD-1 and PD-L1

    Frontiers in Immunology1970journal article

    View DOI
    179 cites

  3. Carbonic anhydrases in metazoan model organisms

    Physiological Reviews1970journal article

    View DOI
    117 cites

  4. Phylogeny and expression of carbonic anhydrase-related proteins

    BMC Molecular Biology1970journal article

    View DOI
    98 cites

  5. Carbonic anhydrase related proteins: Molecular biology and evolution

    Sub-Cellular Biochemistry1970journal article

    View DOI
    78 cites

  6. An update on the metabolic roles of carbonic anhydrases in the model alga chlamydomonas reinhardtii

    Metabolites1970journal article

    View DOI
    68 cites

  7. Zebrafish as a model organism for the development of drugs for skin cancer

    International Journal of Molecular Sciences1970journal article

    View DOI
    60 cites

  8. β-CA-specific inhibitor dithiocarbamate Fc14–584B: a novel antimycobacterial agent with potential to treat drug-resistant tuberculosis

    Journal of Enzyme Inhibition and Medicinal Chemistry1970journal article

    View DOI
    58 cites

  9. Tuberculosis vaccine BCG: the magical effect of the old vaccine in the fight against the COVID-19 pandemic

    International Reviews of Immunology2022journal article

    View DOI
    53 cites

  10. Carbonic anhydrase related protein VIII and its role in neurodegeneration and cancer

    Current Pharmaceutical Design1970journal article

    View DOI
    53 cites

  11. Mitochondrial carbonic anhydrase VA and VB: properties and roles in health and disease

    The Journal of Physiology2023journal article

    View DOI
    50 cites

  12. Abnormal cerebellar development and ataxia in carp VIII morphant zebrafish

    Human Molecular Genetics1970journal article

    View DOI
    48 cites

  13. Mycobacterium tuberculosis β-carbonic anhydrases: Novel targets for developing antituberculosis drugs

    International Journal of Molecular Sciences1970journal article

    View DOI
    46 cites

  14. Medicinal Plants as Therapeutic Alternatives to Combat <i>Mycobacterium tuberculosis</i>: A Comprehensive Review

    Antibiotics2023journal article

    View DOI
    42 cites

  15. Impact of diabetes mellitus on tuberculosis prevention, diagnosis, and treatment from an immunologic perspective

    Exploration2024journal article

    View DOI
    38 cites

  16. Carbonic Anhydrase Inhibitors as Novel Drugs against Mycobacterial β-Carbonic Anhydrases: An Update on In Vitro and In Vivo Studies

    Molecules2018journal article

    View DOI
    38 cites

  17. An update on carbonic anhydrase-related proteins VIII, X and XI

    Journal of Enzyme Inhibition and Medicinal Chemistry1970journal article

    View DOI
    38 cites

  18. Genetic diversity analysis of Blastocystis subtypes and their distribution among the domestic animals and pigeons in northwest of Iran

    Infection, Genetics and Evolution2020journal article

    View DOI
    35 cites

  19. Tuberculosis vaccines and therapeutic drug

    Molecular Biomedicine1970journal article

    View DOI
    30 cites

  20. Carbonic anhydrase related protein expression in astrocytomas and oligodendroglial tumors

    BMC Cancer1970journal article

    View DOI
    28 cites

  21. Advanced nutraceutical approaches to Parkinson's disease

    Nutritional Neuroscience1970journal article

    View DOI
    27 cites

  22. In vitro inhibition of Mycobacterium tuberculosis β-carbonic anhydrase 3 with Mono- and dithiocarbamates and evaluation of their toxicity using zebrafish developing embryos

    Journal of Enzyme Inhibition and Medicinal Chemistry1970journal article

    View DOI
    27 cites

  23. A novel facile synthesis of metal nitride@metal oxide (BN/Gd2O3) nanocomposite and their antibacterial and anticancer activities

    Scientific Reports2023journal article

    View DOI
    26 cites

  24. Design, synthesis, in vitro inhibition and toxicological evaluation of human carbonic anhydrases I, II and IX inhibitors in 5-nitroimidazole series

    Journal of Enzyme Inhibition and Medicinal Chemistry1970journal article

    View DOI
    26 cites

  25. Roles of Carbonic Anhydrases and Carbonic Anhydrase Related Proteins in Zebrafish

    International Journal of Molecular Sciences2022journal article

    View DOI
    22 cites

  26. Nitroimidazole-based inhibitors DTP338 and DTP348 are safe for zebrafish embryos and efficiently inhibit the activity of human CA IX in Xenopus oocytes

    Journal of Enzyme Inhibition and Medicinal Chemistry1970journal article

    View DOI
    21 cites

  27. An update on anticancer drug development and delivery targeting carbonic anhydrase IX

    PeerJ1970journal article

    View DOI
    21 cites

  28. Inactivation of Ca10a and Ca10b genes leads to abnormal embryonic development and alters movement pattern in zebrafish

    PLoS ONE1970journal article

    View DOI
    21 cites

  29. Catalytically inactive carbonic anhydrase-related proteins enhance transport of lactate by MCT1

    FEBS Open Bio1970journal article

    View DOI
    20 cites

  30. Fluorinated benzenesulfonamide anticancer inhibitors of carbonic anhydrase IX exhibit lower toxic effects on zebrafish embryonic development than ethoxzolamide

    Drug and Chemical Toxicology1970journal article

    View DOI
    20 cites

  31. Inhibition Studies on Human and Mycobacterial Carbonic Anhydrases with <i>N</i>-((4-Sulfamoylphenyl)carbamothioyl) Amides

    Molecules2023journal article

    View DOI
    18 cites

  32. Gut microbiota and tuberculosis

    iMeta1970journal article

    View DOI
    17 cites

  33. Analysis of evolution of carbonic anhydrases IV and XV reveals a rich history of gene duplications and a new group of isozymes

    Bioorganic and Medicinal Chemistry1970journal article

    View DOI
    17 cites

  34. Navigating bioactivity space in anti-tubercular drug discovery through the deployment of advanced machine learning models and cheminformatics tools

    Frontiers in Pharmacology2023journal article

    View DOI
    16 cites

  35. Identification and characterization of a novel zebrafish (Danio rerio) pentraxin-carbonic anhydrase

    PeerJ1970journal article

    View DOI
    15 cites

  36. Cloning, purification, kinetic and anion inhibition studies of a recombinant β-carbonic anhydrase from the Atlantic salmon parasite platyhelminth Gyrodactylus salaris

    Journal of Enzyme Inhibition and Medicinal Chemistry2022journal article

    View DOI
    14 cites

  37. Cytokine profile and nitric oxide levels in peritoneal macrophages of BALB/c mice exposed to the fucose-mannose ligand of Leishmania infantum combined with glycyrrhizin

    Parasites and Vectors1970journal article

    View DOI
    14 cites

  38. Toxicity evaluation of sulfamides and coumarins that efficiently inhibit human carbonic anhydrases

    Journal of Enzyme Inhibition and Medicinal Chemistry1970journal article

    View DOI
    14 cites

  39. Mycobacterial β-carbonic anhydrases

    The Enzymes1970book chapter

    View DOI
    13 cites

  40. An Update on the Metabolic Roles of Carbonic Anhydrases in a Model Alga <em>Chlamydomonas reinhardtii</em>

    2018working paper

    View DOI
    12 cites

  41. Evolutionary analysis of WD40 super family proteins involved in spindle checkpoint and RNA export: Molecular evolution of spindle checkpoint

    2008

    View DOI
    12 cites

  42. Elucidating molecular mechanism and chemical space of chalcones through biological networks and machine learning approaches

    Computational and Structural Biotechnology Journal1970journal article

    View DOI
    12 cites

  43. Comparative study of volatile oil constituents, anti-microbial properties, and antibiofilm activities in Eucalyptus camaldulensis and Eucalyptus globulus

    Journal of Essential Oil-Bearing Plants1970journal article

    View DOI
    11 cites

  44. Hypoxia-activated prodrug derivatives of carbonic anhydrase inhibitors in benzenesulfonamide series: Synthesis and biological evaluation

    Molecules1970journal article

    View DOI
    10 cites

  45. Carbonic anhydrases from pathogens: Protozoan CAs and related inhibitors as potential antiprotozoal agents

    Carbonic Anhydrases: Biochemistry and Pharmacology of an Evergreen Pharmaceutical Target1970book chapter

    View DOI
    10 cites

  46. Exploring nature's hidden treasure

    Heliyon2024journal article

    View DOI
    8 cites

  47. Physiological role of bicarbonate in microbes

    Virulence1970journal article

    View DOI
    7 cites

  48. A cheminformatics and network pharmacology approach to elucidate the mechanism of action of Mycobacterium tuberculosis γ-carbonic anhydrase inhibitors

    Frontiers in Pharmacology1970journal article

    View DOI
    7 cites

  49. Targeting Carbonic Anhydrase Isozymes in the Treatment of Neurological Disorders

    The Carbonic Anhydrases: Current and Emerging Therapeutic Targets1970book chapter

    View DOI
    6 cites

  50. Bionomics and phylo-molecular analysis of Leishmania species isolated from human lesions using ITS1 genes in north-east of Iran

    Journal of Parasitic Diseases1970journal article

    View DOI
    6 cites

  51. Revisiting Bacille Calmette-Guérin revaccination strategies

    Clinical and Translational Discovery2024journal article

    View DOI
    5 cites

  52. Sulphonamide inhibition studies of the β-carbonic anhydrase GsaCAβ present in the salmon platyhelminth parasite Gyrodactylus salaris

    Journal of Enzyme Inhibition and Medicinal Chemistry2023journal article

    View DOI
    5 cites

  53. Editorial

    Frontiers in Immunology2023other

    View DOI
    5 cites

  54. Immunogenic properties of empty pcDNA3 plasmid against zoonotic cutaneous leishmaniasis in mice

    PLoS ONE2022journal article

    View DOI
    5 cites

  55. Rapid evaluation of toxicity of chemical compounds using zebrafish embryos

    Journal of Visualized Experiments1970journal article

    View DOI
    5 cites

  56. Physiological modeling of the metaverse of the Mycobacterium tuberculosis β-CA inhibition mechanism

    Computers in Biology and Medicine2024journal article

    View DOI
    4 cites

  57. RETRACTED: Herbal-based nanosystems: A novel drug-delivery treatment procedure against neurodegenerative disorders

    2024preprint

    View DOI
    3 cites

  58. RETRACTED: Exploring the applications of formulation-based drug development strategies in neurological disorders using artificial intelligence and machine learning approaches

    2024

    View DOI
    3 cites

  59. RNAi therapeutics targeting Japanese encephalitis virus

    Virology2026journal article

    View DOI
    2 cites

  60. WITHDRAWN: Molecular Insights into Zea mays Active Phytochemicals for Diabetes and Inflammation Treatment: A Web App-Based Machine Learning and Network Pharmacology Approach

    2024

    View DOI
    2 cites

  61. Evolutionary trajectories of beta-lactamase NDM and DLST cluster in Pseudomonas aeruginosa : finding the putative ancestor

    Pathogens and Global Health2024journal article

    View DOI
    2 cites

  62. Roles of Carbonic Anhydrases and Carbonic Anhydrases Related Proteins in Zebrafish

    2022working paper

    View DOI
    2 cites

  63. Integrated Graph-Based Models Unveil Carbonic Anhydrase VIII, X, XI Expression in Cancer and Neurological Diseases

    2024preprint

    View DOI
    1 cites

  64. A multidimensional network-based approach to elucidate the molecular mechanism underlying tuberculosis and HIV coinfection

    2024preprint

    View DOI
    1 cites

  65. RETRACTED: Nanoparticles of Herbal Extracts in Treatment of Neurodegenerative Disorders

    2024preprint

    View DOI
    1 cites

  66. RETRACTED: Pharmacokinetics-Pharmacodynamics (PK-PD) Modeling: A translational path to brain-targeted drug delivery

    2024preprint

    View DOI
    1 cites

  67. WITHDRAWN: Mechanistic modelling of Mycobacterium Tuberculosis beta carbonic anhydrase 3 inhibitors

    2024

    View DOI
    1 cites

  68. WITHDRAWN: Neural Network and Random Forest Algorithms as Catalysts in QSAR/QSAAR Modeling: Targeting Carbonic Anhydrase for Antituberculosis Drug Design

    2024

    View DOI
    1 cites

  69. Corrigendum: Navigating bioactivity space in anti-tubercular drug discovery through the deployment of advanced machine learning models and cheminformatics tools: a molecular modeling based retrospective study

    2024

    View DOI
    1 cites

  70. Integrated machine learning-driven QSAR modelling and systems biology approach for the identification of potential SARS-CoV-2 3CLpro inhibitors

    SAR and QSAR in Environmental Research1970journal article

    View DOI
    1 cites

  71. Editorial

    Frontiers in Immunology1970other

    View DOI
    1 cites

  72. Making sense of carbonic anhydrase function in zebrafish using antisense morpholinos

    Molecular Genetics and Genomics1970journal article

    View DOI
    1 cites

  73. Efficacy of Novel CA IX Inhibitors in Biological Models

    Carbonic Anhydrase as Drug Target : Thermodynamics and Structure of Inhibitor Binding1970book chapter

    View DOI
    1 cites

  74. Carbonic Anhydrase XIII

    Carbonic Anhydrases as Biocatalysts: From Theory to Medical and Industrial Applications1970book chapter

    View DOI
    1 cites

  75. Systematic modeling of porphyrin-based photosensitizers for inhibiting Mycobacterium tuberculosis β-Carbonic Anhydrases

    Scientific Reports2026journal article

    View DOI
    0 cites

  76. When the host is not healthy

    Tuberculosis2026journal article

    View DOI
    0 cites

  77. An integrated network-based approach to elucidate the molecular mechanism behind Tuberculosis and HIV co-infection

    2026

    View DOI
    0 cites

  78. Combating Drug Resistance in Mycobacterium Tuberculosis : A Combinatorial in Silico and Experimental Modeling Approach Toward Novel ATP Synthase Inhibitor Discovery

    Bioinformatics and Biology Insights2026journal article

    View DOI
    0 cites

  79. Exploring the Potential of Coumarins against the Flavoenzyme DprE1 forAnti-TB Activity: Insights from Molecular Docking, In silico Druglikeness,ADMET, MD Simulations, MMGBSA, and DFT Studies

    2026

    View DOI
    0 cites

  80. Integrated in silico and in vitro screening approaches for the discovery of small-molecule inhibitors of β-carbonic anhydrases

    Expert Opinion on Drug Discovery2026journal article

    View DOI
    0 cites

  81. Contributors

    2026

    View DOI
    0 cites

  82. Chalcones as antibacterial and antitubercular agents

    2026

    View DOI
    0 cites

  83. Mitochondrial carbonic anhydrases VA and VB: Metabolic roles and clinical significance

    2026

    View DOI
    0 cites

  84. Carbonic anhydrase-related proteins VIII, X, and XI: Evolutionary divergence and emerging biological roles

    2026

    View DOI
    0 cites

  85. Tuberculosis Vaccines

    Vaccines2025other

    View DOI
    0 cites

  86. Exploring the functional food potential of Zea mays using machine learning–based QSAR and network biology to identify anti-diabetic and anti-inflammatory phytochemicals

    International Journal of Food Science and Technology2025journal article

    View DOI
    0 cites

  87. Inside Back Cover: Impact of diabetes mellitus on tuberculosis prevention, diagnosis, and treatment from an immunologic perspective (EXP2 5/2024)

    2024

    View DOI
    0 cites

  88. A data and knowledge-driven integrated modeling approach to organ-specific Tuberculosis subtype discovery: A one health paradigm

    2024preprint

    View DOI
    0 cites

  89. APV9WR: An Integrated Web Resource of Alpha papillomavirus 9 for Genomics, Proteomics, Phylogenetic and Therapeutic Analysis

    2024

    View DOI
    0 cites

  90. A multi-dimensional systems biology approach to elucidate the mechanism of action of Mycobacterium tuberculosis γ-carbonic anhydrase inhibitors

    2024preprint

    View DOI
    0 cites

  91. WITHDRAWN: Physiological modeling into the metaverse of Mycobacterium Tuberculosis Beta CA inhibition mechanism

    2024

    View DOI
    0 cites

  92. WITHDRAWN: Physiological modeling and biomechanical insights of cytokine modulation in COVID-19 and pulmonary fibrosis through a multi-dimensional graph-based approach

    2024

    View DOI
    0 cites

  93. WITHDRAWN: Elucidating the molecular mechanism of phytochemicals against Parkinson’s disease through an integrated systems biology and molecular modeling approach

    2024

    View DOI
    0 cites

  94. WITHDRAWN: Mechanistic modeling of Mycobacterium tuberculosis β-carbonic anhydrase inhibitors using integrated systems biology and the QSAR approach

    2024

    View DOI
    0 cites

  95. Elucidating Molecular Mechanism and Chemical Space of Chalcones through Knowledge Graph and Machine Learning: A Combined Bio-Cheminformatic Pipeline

    2024preprint

    View DOI
    0 cites

  96. WITHDRAWN: Multimolecular feature-based machine learning: system biology enhanced RF-QSAR modeling for the efficient prediction of the inhibitory potential of diverse SARS CoV-2 3CL Protease inhibitors

    2024

    View DOI
    0 cites

  97. SARS-CoV-2 variants and COVID-19 vaccines: Current challenges and future strategies

    International Reviews of Immunology2022journal article

    View DOI
    0 cites

  98. COVID-19 pandemic: SARS-CoV-2 specific vaccines and challenges, protection via BCG trained immunity, and clinical trials.

    Expert review of vaccines2021journal article

    View DOI
    0 cites

  99. COVID-19 pandemic: SARS-CoV-2 specific vaccines and challenges, protection via BCG trained immunity, and clinical trials

    Expert Review of Vaccines2021journal article

    View DOI
    0 cites

  100. Cytokine profile and nitric oxide levels in peritoneal macrophages of BALB/c mice exposed to Fucose-Mannose Ligand of Leishmania infantum combined with Glycyrrhizin

    2020

    View DOI
    0 cites

  101. イラン北西部の家畜とハトにおけるBlastocystisサブタイプの遺伝的多様性解析とそれらの分布【JST・京大機械翻訳】

    2020

    0 cites

  102. Carbonic anhydrases from pathogens: protozoan CAs and related inhibitors as potential antiprotozoal agents

    Carbonic Anhydrases Biochemistry and Pharmacology of an Evergreen Pharmaceutical Target2019book chapter

    0 cites

  103. List of contributors

    2019

    View DOI
    0 cites

  104. Additional file 2: of Carbonic anhydrase related protein expression in astrocytomas and oligodendroglial tumors

    2018

    View DOI
    0 cites

  105. Additional file 1: of Carbonic anhydrase related protein expression in astrocytomas and oligodendroglial tumors

    2018

    View DOI
    0 cites

  106. Additional file 3: of Carbonic anhydrase related protein expression in astrocytomas and oligodendroglial tumors

    2018

    View DOI
    0 cites

  107. Additional file 4: of Carbonic anhydrase related protein expression in astrocytomas and oligodendroglial tumors

    2018

    View DOI
    0 cites

  108. Peer Review #2 of "Identification and characterization of a novel zebrafish (Danio rerio) pentraxin–carbonic anhydrase (v0.1)"

    2017

    View DOI
    0 cites

  109. Peer Review #2 of "An update on anticancer drug development and delivery targeting carbonic anhydrase IX (v0.2)"

    2017

    View DOI
    0 cites

  110. Zebrafish as a Model Organism for the Development of Drugs for Skin Cancer.

    Int. J. Mol. Sci.2017journal article

    View DOI
    0 cites

  111. Carbonic Anhydrase XIII

    Carbonic anhydrase XIII. In, Carbonic Anhydrases as Biocatalysts: From Theory to Medical and Industrial Applications.2015book chapter

    0 cites

  112. Ataxic movement in 5dpf morphant fish!

    2015

    View DOI
    0 cites

  113. List of Contributors

    2015

    View DOI
    0 cites

  114. Distribution and Function of Carbonic Anhydrase Related Proteins (CARPs) VIII, X and XI

    2014

    0 cites

  115. Hiilihappoanhydraasien kaltaisten proteiinien VIII, X ja XI ilmentyminen ja toiminta

    2014

    0 cites

  116. Analysis of carbonic anhydrase related proteins VIII, X, and XI

    2013

    0 cites

  117. Computational and Experimental Characterization of Mycobacterium marinum β-Carbonic Anhydrase Inhibitors

    Bioinformatics and Biology Insights1970journal article

    View DOI
    0 cites

  118. Prognostic implications of TIMP1 gene expression in colon Adenocarcinoma

    Network Modeling Analysis in Health Informatics and Bioinformatics1970journal article

    View DOI
    0 cites

  119. Community series in research advances of tuberculosis vaccine and its implication on COVID-19

    Frontiers in Immunology1970journal issue

    0 cites

  120. A Predictive ML-QSAR Approach for Targeting GSK-3β in Alzheimer's Disease

    Advanced theory and simulations1970journal article

    View DOI
    0 cites

  121. Special Issue: Research Progress of New Tuberculosis Vaccines and Vaccine Design

    Vaccines1970journal issue

    0 cites

  122. Dosentit - yliopiston merkittävä voimavara

    Tampereen dosenttiyhdistyksen julkaisuja1970book

    0 cites

  123. Research Topic: Research Advances of Tuberculosis Vaccine and its Implication on COVID-19

    Frontiers in Immunology1970journal issue

    0 cites

  124. Distribution and Function of Carbonic Anhydrase Related Proteins (CARPs) VIII, X and XI

    Acta Universitatis Tamperensis1970dissertation thesis

    0 cites

  125. Evolutionary analysis of WD40 super family proteins involved in spindle checkpoint and RNA export: molecular evolution of spindle checkpoint

    Bioinformation1970journal article

    0 cites

  126. SARS-CoV-2 variants and COVID-19 vaccines

    International Reviews of Immunology1970journal article

    View DOI
    0 cites