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Chandrabose Karthikeyan

University of Arkansas for Medical SciencesIN
ORCID0000-0002-9074-9554
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27

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Citations
2,384

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Publications
104

About

Chandrabose Karthikeyan is a researcher at the University of Arkansas for Medical Sciences. With over 104 publications spanning from 1970 to 2026, his work primarily focuses on quantitative structure-activity relationships (QSAR) and their applications in medicinal chemistry, particularly in the areas of anti-cancer agents, anti-inflammatory compounds, and targeted drug delivery.

Research areas

  • Chemistry
  • Medicine
  • Biology
  • Biochemistry
  • Organic chemistry

Publications (104)

Sorted by most cited.

  1. QSAR modelling of HIV-1 reverse transcriptase inhibition by benzoxazinones using a combination of P_VSA and pharmacophore feature descriptors

    Bioorganic and Medicinal Chemistry Letters1970journal article

    View DOI
    24 cites

  2. QSAR analysis of some phthalimide analogues based inhibitors of HIV-1 integrase

    Arkivoc1970journal article

    15 cites

  3. Multi-algorithm based machine learning and structural pattern studies for hERG ion channel blockers mediated cardiotoxicity prediction

    Chemometrics and Intelligent Laboratory Systems1970journal article

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    10 cites

  4. Modeling VEGFR kinase inhibition of aminopyrazolopyridine urea derivatives using topological and physicochemical descriptors: A quantitative structure activity analysis study

    Medicinal Chemistry Research1970journal article

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    4 cites

  5. QSAR study on hetaryl imidazoles: A novel dual inhibitor of VEGF receptors I and II

    Medicinal Chemistry1970journal article

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    2 cites

  6. Antiplasmodial metabolites from Baccharoides anthelmintica seeds: In vitro and in silico profiling

    Journal of Ethnopharmacology2026journal article

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    0 cites

  7. Medicinal Aspects of PTP1B Inhibitors as Anti-Breast Cancer Agents: An Overview

    Current Medicinal Chemistry2024journal article

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    0 cites

  8. In silico-guided discovery and in vitro validation of novel sugar-tethered lysinated carbon nanotubes for targeted drug delivery of doxorubicin

    Journal of Molecular Modeling2024journal article

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    0 cites

  9. Use of lysinated multiwalled carbon nanotubes with carbohydrate ligands as a doxorubicin nanocarrier: A molecular dynamics analysis

    Carbon Trends2023journal article

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    0 cites

  10. A QSAR analysis of some amino substituted Pyrido[3,2-b]pyrazinones as potent and selective PDE-5 inhibitors

    2010

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    0 cites

  11. Stability-Indicating Assay Method for Estimation of Olmesartan Medoxomil and its Metabolite

    Journal of Liquid Chromatography & Related Technologies2009journal article

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    0 cites

  12. Microwave-Assisted Functionalization of Multi-Walled Carbon Nanotubes for Biosensor and Drug Delivery Applications

    Pharmaceutics1970journal article

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    0 cites

  13. Classification analysis of fatty acid synthase inhibitors using multialgorithms on topological descriptors and structural fingerprints

    Chemical Biology and Drug Design1970journal article

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    0 cites

  14. Computer-Assisted Drug Design: A Toolbox for Novel Tau Kinase Inhibitors and Its Implications in Alzheimer’s Disease

    Neuromethods1970book chapter

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    0 cites

  15. Multifunctional GQDs for receptor targeting, drug delivery, and bioimaging in pancreatic cancer

    Nanoscale1970journal article

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    0 cites

  16. IND-2, a Quinoline Derivative, Inhibits the Proliferation of Prostate Cancer Cells by Inducing Oxidative Stress, Apoptosis and Inhibiting Topoisomerase II

    Life1970journal article

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    0 cites

  17. Lysinated Multiwalled Carbon Nanotubes with Carbohydrate Ligands as an Effective Nanocarrier for Targeted Doxorubicin Delivery to Breast Cancer Cells

    Molecules1970journal article

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    0 cites

  18. Substituent Orchestration in Dimethylquinoxaline Derivatives: A Tool for Fishing Out Appropriate CDK5 Inhibitors as Potential Therapeutics for Alzheimer's

    Chemistry and Biodiversity1970journal article

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    0 cites

  19. Targeting Angiotensin-converting Enzyme 2 (ACE2) for the Discovery of Anticoronaviral Drugs

    Coronaviruses1970journal article

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    0 cites

  20. Design, synthesis and biological evaluation of 3-(2-(benzo[d]thiazol-2-ylthio)acetamido)benzoic acid derivatives as inhibitors of protein tyro-sine phosphatase 1b

    Letters in Drug Design and Discovery1970journal article

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    0 cites

  21. A novel dialkylamino-functionalized chalcone, DML6, inhibits cervical cancer cell proliferation, in vitro, via induction of oxidative stress, intrinsic apoptosis and mitotic catastrophe

    Molecules1970journal article

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    0 cites

  22. Antiproliferative efficacy of n-(3-chloro-4-fluorophenyl)-6, 7-dimethoxyquinazolin-4-amine, dw-8, in colon cancer cells is mediated by intrinsic apoptosis

    Molecules1970journal article

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    0 cites

  23. Lead optimization of novel quinolone chalcone compounds by a structure-activity relationship (SAR) study to increase efficacy and metabolic stability

    ResearchSquare1970other

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    0 cites

  24. Lead optimization of novel quinolone chalcone compounds by a structure–activity relationship (SAR) study to increase efficacy and metabolic stability

    Scientific Reports1970journal article

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    0 cites

  25. The Rise and Fall of Chloroquine/Hydroxychloroquine as Compassionate Therapy of COVID-19

    Frontiers in Pharmacology1970journal article

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    0 cites

  26. Unravelling the Selectivity of 6,7-Dimethyl Quinoxaline Analogs for Kinase Inhibition: An Insight towards the Development of Alzheimer's Therapeutics

    Chemistry and Biodiversity1970journal article

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    0 cites

  27. Virtual screening based discovery of PTP1B inhibitors and their biological evaluations

    Letters in Drug Design and Discovery1970journal article

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    0 cites

  28. Abacavir induces the transcriptional activity of YY1 and other oncogenic transcription factors in gastric cancer cells

    Antiviral Research1970journal article

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    0 cites

  29. In search of novel tau kinase inhibitors and their role in alzheimer’s therapy

    A Closer Look at Kinase Inhibition1970book chapter

    0 cites

  30. Recent advances in the development of fatty acid synthase inhibitors as anticancer agents

    Mini-Reviews in Medicinal Chemistry1970journal article

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    0 cites

  31. Design, synthesis and biological evaluation of some tetrazole acetamide derivatives as novel non-carboxylic PTP1B inhibitors

    Bioorganic Chemistry1970journal article

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    0 cites

  32. Natural polysaccharides: Structural features and properties

    Polysaccharide Carriers for Drug Delivery1970book chapter

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    0 cites

  33. Novel 3-((2-chloroquinolin-3-yl)methylene)indolin-2-one derivatives produce anticancer efficacy in ovarian cancer in vitro

    Heliyon1970journal article

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    0 cites

  34. Novel thienopyrimidine derivative, RP-010, induces β-catenin fragmentation and is efficacious against prostate cancer cells

    Cancers1970journal article

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    0 cites

  35. The Novel Thienopyrimidine Derivative, RP-010, Produces Its Efficacy in Prostate Cancer Cells by Inducing the Fragmentation of β-catenin

    1970other

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    0 cites

  36. Unravelling the potency of 4,5-diamino-4H-1,2,4 triazole-3-thiol derivatives for kinase inhibition using a rational approach

    New Journal of Chemistry1970journal article

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    0 cites

  37. Bax/Tubulin/Epithelial-mesenchymal pathways determine the efficacy of silybin analog HM015k in colorectal cancer cell growth and metastasis

    Frontiers in Pharmacology1970journal article

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    0 cites

  38. Cariprazine, a dopamine D<sub>2</sub>/D<sub>3</sub> receptor partial agonist, modulates ABCG2-mediated multidrug resistance in cancer

    Cancers1970journal article

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    0 cites

  39. Recent advances in protein tyrosine phosphatase 1b targeted drug discovery for Type II diabetes and obesity

    Current Drug Targets1970journal article

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    0 cites

  40. Synthesis and biological evaluation of some N-(3-(1H-tetrazol-5-yl) phenyl)acetamide derivatives as novel non-carboxylic PTP1B inhibitors designed through bioisosteric modulation

    Bioorganic Chemistry1970journal article

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    0 cites

  41. lH-Pyrazolo[3,4-b]quinolin-3-amine derivatives inhibit growth of colon cancer cells via apoptosis and sub G1 cell cycle arrest

    Bioorganic and Medicinal Chemistry Letters1970journal article

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    0 cites

  42. 2,3-Diaryl-3H-imidazo[4,5-b]pyridine derivatives as potential anticancer and anti-inflammatory agents

    Acta Pharmaceutica Sinica B1970journal article

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    0 cites

  43. A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma

    Oncotarget1970journal article

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    0 cites

  44. Design and discovery of silybin analogues as antiproliferative compounds using a ring disjunctive – Based, natural product lead optimization approach

    European Journal of Medicinal Chemistry1970journal article

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    0 cites

  45. HM015k, a novel silybin derivative, multi-targets metastatic ovarian cancer cells and is safe in zebrafish toxicity studies

    Frontiers in Pharmacology1970journal article

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    0 cites

  46. Mechanisms of the anti-tumor activity of Methyl 2-(-5-fluoro-2- hydroxyphenyl)-1 H-benzo[d]imidazole-5-carboxylate against breast cancer in vitro and in vivo

    Oncotarget1970journal article

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    0 cites

  47. N-(1H-Pyrazol-3-yl)quinazolin-4-amines as a novel class of casein kinase 1d/e inhibitors: Synthesis, biological evaluation and molecular modeling studies

    Bioorganic and Medicinal Chemistry Letters1970journal article

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    0 cites

  48. Novel quinolone chalcones targeting colchicine-binding pocket kill multidrug-resistant cancer cells by inhibiting tubulin activity and MRP1 function

    Scientific Reports1970journal article

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    0 cites

  49. Synthesis and biological evaluation of 2-(phenyl)-3H-benzo[d]imidazole-5-carboxylic acids and its methyl esters as potent anti-breast cancer agents

    Arabian Journal of Chemistry1970journal article

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    0 cites

  50. Synthesis, antifungal evaluation and in silico study of novel Schiff bases derived from 4-amino-5(3,5-dimethoxy-phenyl)-4H-1,2,4-triazol-3-thiol

    Arabian Journal of Chemistry1970journal article

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    0 cites

  51. Synthesis, characterization and anti cancer activity of some fluorinated 3,6-diaryl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles

    Arabian Journal of Chemistry1970journal article

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    0 cites

  52. The dopamine D<inf>3</inf> receptor antagonists PG01037, NGB2904, SB277011A, and U99194 reverse ABCG2 transporter-mediated drug resistance in cancer cell lines

    Cancer Letters1970journal article

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    0 cites

  53. Thienopyrimidine derivatives exert their anticancer efficacy via apoptosis induction, oxidative stress and mitotic catastrophe

    European Journal of Medicinal Chemistry1970journal article

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    0 cites

  54. A new simple and rapid validated RP-HPLC method for determination of ziprasidone in ziprasidone capsules

    Journal of Saudi Chemical Society1970journal article

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    0 cites

  55. Pyrimido[1¿,2¿:1,5]pyrazolo[3,4-b]quinolines: Novel compounds that reverse ABCG2-mediated resistance in cancer cells

    Cancer Letters1970journal article

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    0 cites

  56. Synthesis, characterization and cytotoxicity studies of CuO nanoparticles by using Gymnema sylvestre leaf extracts

    Journal of the Indian Chemical Society1970journal article

    0 cites

  57. Targeting of tubulin polymerization and induction of mitotic blockage by Methyl 2-(5-fluoro-2-hydroxyphenyl)-1H-benzo[d]imidazole-5-carboxylate (MBIC) in human cervical cancer HeLa cell

    Journal of Experimental and Clinical Cancer Research1970journal article

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    0 cites

  58. Advances in chalcones with anticancer activities

    Recent Patents on Anti-Cancer Drug Discovery1970journal article

    0 cites

  59. Advances in chalcones with anticancer activities

    Recent Patents on Anti-Cancer Drug Discovery1970journal article

    0 cites

  60. IND-2, a pyrimido[1¿,2¿:1,5]pyrazolo[3,4-b]quinoline derivative, circumvents multi-drug resistance and causes apoptosis in colon cancer cells

    Bioorganic and Medicinal Chemistry1970journal article

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    0 cites

  61. Stearidonic acid, a plant-based dietary fatty acid, enhances the chemosensitivity of canine lymphoid tumor cells

    Biochemical and Biophysical Research Communications1970journal article

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    0 cites

  62. Synthesis, characterization and biological evaluation of N-(5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl)-4-nitrobenzamide derivatives

    Der Pharma Chemica1970journal article

    0 cites

  63. Synthesis, characterization and biological evaluation of N-(5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl)-4-nitrobenzamide derivatives

    Der Pharma Chemica1970journal article

    0 cites

  64. Analysis of surface area features of structurally diverse molecules for Bcr/Abl kinase inhibitory activity and antiproliferative activity

    Medicinal Chemistry Research1970journal article

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    0 cites

  65. Human CDC2-like kinase 1 (CLK1): A novel target for Alzheimer's disease

    Current Drug Targets1970journal article

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    0 cites

  66. Synthesis, biological evaluation and molecular modelling studies of 4-anilinoquinazoline derivatives as protein kinase inhibitors

    Bioorganic and Medicinal Chemistry1970journal article

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    0 cites

  67. 6H-indolo[2,3-b]quinoxalines: DNA and protein interacting scaffold for pharmacological activities

    Mini-Reviews in Medicinal Chemistry1970journal article

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    0 cites

  68. Design, synthesis and biological evaluation of novel arylidine- malononitrile derivatives as non-carboxylic inhibitors of protein tyrosine phosphatase 1B

    Medicinal Chemistry Research1970journal article

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    0 cites

  69. Design, synthesis and biological evaluation of some isatin-linked chalcones as novel anti-breast cancer agents: A molecular hybridization approach

    Biomedicine and Preventive Nutrition1970journal article

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    0 cites

  70. Design, synthesis and molecular modelling studies of novel 3-acetamido-4-methyl benzoic acid derivatives as inhibitors of protein tyrosine phosphatase 1B

    European Journal of Medicinal Chemistry1970journal article

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    0 cites

  71. Nimesulide and celecoxib inhibits multiple oncogenic pathways in gastric cancer cells

    Journal of Cancer Science and Therapy1970journal article

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    0 cites

  72. Synthesis and evaluation of some amino acid conjugates of pirprofen

    Biomedicine and Preventive Nutrition1970journal article

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  73. Synthesis and evaluation of some amino acid conjugates of suprofen

    Biomedicine and Preventive Nutrition1970journal article

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  74. Design, synthesis and biological evaluation of some novel 3-cinnamoyl-4-hydroxy-2H-chromen-2-ones as antimalarial agents

    Medicinal Chemistry Research1970journal article

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    0 cites

  75. Localized delivery of cisplatin for the effective management of squamous cell carcinoma from protransfersome formulation

    Archives of Pharmacal Research1970journal article

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    0 cites

  76. Synthesis, in silico metabolic and toxicity prediction of some novel imidazolinones derivatives as potent anticonvulsant agents

    Journal of Enzyme Inhibition and Medicinal Chemistry1970journal article

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  77. A risk assessment approach: Qualification of a HVAC system in aseptic processing area using building management system

    Quality Assurance Journal1970journal article

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  78. A validated UPLC method used for the determination of trandolapril and its degradation products as per ICH guidelines

    Current Pharmaceutical Analysis1970journal article

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  79. Comparative study of forced degradation behavior of prasugrel by uplc and hplc and the development of validated stability indicating assay method

    Journal of Liquid Chromatography and Related Technologies1970journal article

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  80. Determination of salmeterol xinafoate and its degradation products according to ICH guidelines with use of UPLC technique

    Latin American Journal of Pharmacy1970journal article

    0 cites

  81. Development and validation of a RP-HPLC method for determination of citicoline monosodium in human plasma

    Latin American Journal of Pharmacy1970journal article

    0 cites

  82. RP-HPLC method for estimation and stability study of drotaverine HCl as per ICH guidelines

    Latin American Journal of Pharmacy1970journal article

    0 cites

  83. RP-HPLC method for simultaneous estimation of amlodipine and valsartan in tablet formulation and validation as per ICH guidelines

    Latin American Journal of Pharmacy1970journal article

    0 cites

  84. Study of forced degradation behaviour of eprosartan mesylate and development of validated stability indicating assay method by UPLC

    Latin American Journal of Pharmacy1970journal article

    0 cites

  85. Synthesis of some coumarinyl chalcones and their antiproliferative activity against breast cancer cell lines

    Letters in Drug Design and Discovery1970journal article

    0 cites

  86. 3D QSAR of aminophenyl benzamide derivatives as histone deacetylase inhibitors

    Medicinal Chemistry1970journal article

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  87. A new approach for PEGylation of dendrimers

    Bioorganic and Medicinal Chemistry Letters1970journal article

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  88. Design, synthesis and characterization of novel 1,3,4-oxadiazole dimers from benzoic acids

    International Journal of ChemTech Research1970journal article

    0 cites

  89. Design, synthesis, cytotoxic evaluation, and QSAR study of some 6H-indolo[2,3-b]quinoxaline derivatives

    Journal of Enzyme Inhibition and Medicinal Chemistry1970journal article

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  90. QSAR analysis of HIV-1 reverse transcriptase inhibitory 5-alkyl-2- [(aryl and alkyloxylcarbonylmethyl) thio]-6- (1-napthylmethyl) pyrimidin-4 (3H)-ones

    International Journal of Virology1970journal article

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  91. The ICH guidance in practice: Stress degradation studies on irbesartan and development of a validated stability-indicating UPLC assay

    Acta Chromatographica1970journal article

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  92. QSAR study of substituted 2-pyridinyl guanidines as selective urokinase-type plasminogen activator (uPA) inhibitors

    Journal of Enzyme Inhibition and Medicinal Chemistry1970journal article

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  93. QSAR study on N-(aryl)-4-(azolylethyl) thiazole-5-carboxamides: Novel potent inhibitors of VEGF receptors I and II

    Medicinal Chemistry1970journal article

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  94. Quantitative structure activity relationship studies of piperazinyl phenylalanine derivatives as VLA-4/VCAM-1 inhibitors

    Medicinal Chemistry1970journal article

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  95. Simultaneous quantitative determination of zidovudine and nevirapine in human plasma using isocratic, reverse phase high performance liquid chromatography

    Tropical Journal of Pharmaceutical Research1970journal article

    0 cites

  96. Synthesis, cytotoxic evaluation and in silico pharmacokinetic prediction of some benzo[a]phenazine-5-sulfonic acid derivatives

    Medicinal Chemistry1970journal article

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  97. Quantitative structure activity analysis of 2-alkoxydihydrocinnamates as PPARα/γ dual agonist

    Medicinal Chemistry1970journal article

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  98. Quantitative structure activity relationship analysis of some diarylsulphonylurea derivatives as tubulin binding agents

    International Journal of Cancer Research1970journal article

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  99. QSAR analysis of HIV-1 reverse transcriptase inhibitory 5-alkyl-2-[(aryl and alkyloxycarbonlmethyl) thio]-6- (1-napthylmethyl) pyrimidin-4 (3H)-ones

    International Journal of Virology1970journal article

    0 cites

  100. QSAR studies of cytotoxic acridine 5,7-diones: A comparative study using P-VSA descriptors and topological descriptors

    Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry1970journal article

    0 cites

  101. New spectrophotometric methods applied to the simultaneous determination of diclofenac potassium and tizanidine

    Indian Journal of Pharmaceutical Sciences1970journal article

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  102. QSAR analysis of some 5-amino-2-mercapto-1,3,4-thiadiazole based inhibitors of matrix metalloproteinases and bacterial collagenase

    Bioorganic and Medicinal Chemistry Letters1970journal article

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  103. Quantitative structure-activity relationships of selective antagonists of glucagon receptor using QuaSAR descriptors

    Chemical and Pharmaceutical Bulletin1970journal article

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  104. Simultaneous spectrophotometry methods for the estimation of nimesulide and tizanidine in a tablet dosage form

    Indian Journal of Pharmaceutical Sciences1970journal article

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