Skip to content
GraphTheory.in

Manish Gupta

University of Central FloridaIN
ORCID0000-0002-1949-2231
Claim this profile
h-index
44

via OpenAlex

Citations
5,749

via OpenAlex

Publications
65

About

Manish Gupta is a researcher affiliated with the University of Central Florida. With over 65 publications spanning from 1970 to 2024, he has focused on computational modeling and prediction of biological activity, particularly in the fields of medicinal chemistry and pharmacology.

Research areas

  • Chemistry
  • Medicine
  • Biology
  • Internal medicine
  • Biochemistry

Publications (65)

Sorted by most cited.

  1. CP-MLR/PLS directed structure-activity modeling of the HIV-1 RT inhibitory activity of 2,3-diaryl-1,3-thiazolidin-4-ones

    QSAR and Combinatorial Science1970journal article

    View DOI
    72 cites

  2. Topological descriptors in modeling the HIV inhibitory activity of 2-aryl-3-pyridyl-thiazolidin-4-ones

    Combinatorial Chemistry and High Throughput Screening1970journal article

    View DOI
    46 cites

  3. CP-MLR directed QSAR studies on the antimycobacterial activity of functionalized alkenols-topological descriptors in modeling the activity

    Bioorganic and Medicinal Chemistry1970journal article

    View DOI
    41 cites

  4. QSAR study on tetrahydroquinoline analogues as plasmodium protein farnesyltransferase inhibitors: A comparison of rationales of malarial and mammalian enzyme inhibitory activities for selectivity

    European Journal of Medicinal Chemistry1970journal article

    View DOI
    23 cites

  5. Atom-based 3D-QSAR, molecular docking and molecular dynamics simulation assessment of inhibitors for thyroid hormone receptor α and β

    2014

    View DOI
    11 cites

  6. CP-MLR/PLS directed QSAR study on the glutaminyl cyclase inhibitory activity of imidazoles: rationales to advance the understanding of activity profile

    Journal of Enzyme Inhibition and Medicinal Chemistry1970journal article

    View DOI
    11 cites

  7. Modeling of antitubercular activity of biphenyl analogs of 2-nitroimidazo[2,1-b][1,3]oxazine to rationalize their activity profile

    Medicinal Chemistry Research1970journal article

    View DOI
    7 cites

  8. CP-MLR/PLS-directed QSAR studies on the antimalarial activity and cytotoxicity of substituted 4-aminoquinolines

    Medicinal Chemistry Research1970journal article

    View DOI
    4 cites

  9. Endophytic Fungi: A Treasure Trove of Antifungal Metabolites

    Microorganisms2024journal article

    View DOI
    0 cites

  10. Benzoflavone derivatives as potent antihyperuricemic agents

    MedChemComm1970journal article

    View DOI
    0 cites

  11. Correction: Benzoflavone derivatives as potent antihyperuricemic agents(MedChemCommun (2019) DOI: 10.1039/c8md00512e)

    MedChemComm1970journal article

    View DOI
    0 cites

  12. Design, synthesis, antimicrobial evaluation, and molecular modeling studies of novel indolinedione-coumarin molecular hybrids

    ACS Omega1970journal article

    View DOI
    0 cites

  13. Nanoscale drug delivery strategies for therapy of ovarian cancer: conventional vs targeted

    Artificial Cells, Nanomedicine and Biotechnology1970journal article

    View DOI
    0 cites

  14. Mangrove-associated fungi: A novel source of potential anticancer compounds

    Journal of Fungi1970journal article

    View DOI
    0 cites

  15. Endophytic fungi: A source of potential antifungal compounds

    Journal of Fungi1970journal article

    View DOI
    0 cites

  16. 5,6-Benzoflavones as cholesterol esterase inhibitors: Synthesis, biological evaluation and docking studies

    MedChemComm1970journal article

    View DOI
    0 cites

  17. Molecular Docking Studies on Isocytosine Analogues as Xanthine Oxidase Inhibitors

    Drug Research1970journal article

    View DOI
    0 cites

  18. Benzoflavones as cholesterol esterase inhibitors: Synthesis, biological evaluation and docking studies

    Bioorganic and Medicinal Chemistry Letters1970journal article

    View DOI
    0 cites

  19. Recent synthetic and medicinal perspectives of dihydropyrimidinones: A review

    European Journal of Medicinal Chemistry1970journal article

    View DOI
    0 cites

  20. Synthesis, screening and docking of fused pyrano[3,2-d]pyrimidine derivatives as xanthine oxidase inhibitor

    European Journal of Medicinal Chemistry1970journal article

    View DOI
    0 cites

  21. Thiazolidinone Constraint Combretastatin Analogs as Novel Antitubulin Agents: Design, Synthesis, Biological Evaluation and Docking Studies

    Anti-cancer agents in medicinal chemistry1970journal article

    0 cites

  22. Thiazolidinone constraint combretastatin analogs as novel antitubulin agents: Design, synthesis, biological evaluation and docking studies

    Anti-Cancer Agents in Medicinal Chemistry1970journal article

    View DOI
    0 cites

  23. Triazole tethered isatin-coumarin based molecular hybrids as novel antitubulin agents: Design, synthesis, biological investigation and docking studies

    Bioorganic and Medicinal Chemistry Letters1970journal article

    View DOI
    0 cites

  24. Impact of Artificial Neural Networks in QSAR and Computational Modeling

    Artificial Neural Network for Drug Design, Delivery and Disposition1970book

    View DOI
    0 cites

  25. Triazole tethered C<inf>5</inf>-curcuminoid-coumarin based molecular hybrids as novel antitubulin agents: Design, synthesis, biological investigation and docking studies

    European Journal of Medicinal Chemistry1970journal article

    View DOI
    0 cites

  26. Herbs to curb cyclic nucleotide phosphodiesterase and their potential role in Alzheimer's disease

    Mechanisms of Ageing and Development1970journal article

    View DOI
    0 cites

  27. Quinoline and quinolones: Promising scaffolds for future antimycobacterial agents

    Journal of Enzyme Inhibition and Medicinal Chemistry1970journal article

    View DOI
    0 cites

  28. Screening of a library of 4-aryl/heteroaryl-4H-fused pyrans for xanthine oxidase inhibition: Synthesis, biological evaluation and docking studies

    Medicinal Chemistry Research1970journal article

    View DOI
    0 cites

  29. Triazole linked mono carbonyl curcumin-isatin bifunctional hybrids as novel anti tubulin agents: Design, synthesis, biological evaluation and molecular modeling studies

    Bioorganic and Medicinal Chemistry1970journal article

    View DOI
    0 cites

  30. 3D-QSAR analysis on 6-(1-benzyl-1H-pyrrol-2-yl)-2, 4-dioxo-5-hexenoic acid derivatives as recombinant HIV-1 integrase inhibitors

    Der Pharma Chemica1970journal article

    0 cites

  31. 4,6-Diaryl/heteroarylpyrimidin-2(1H)-ones as a new class of xanthine oxidase inhibitors

    Archiv der Pharmazie1970journal article

    View DOI
    0 cites

  32. A novel integrase targeting agent to explore the future prospective of HIV eradication: Dolutegravir

    Current HIV Research1970journal article

    View DOI
    0 cites

  33. Amphiphile catalysed selective synthesis of 4-amino alkylated-1H-pyrazol-5-ol via Mannich aromatization preferred to the Knoevenagel-Michael type reaction in water

    RSC Advances1970journal article

    View DOI
    0 cites

  34. Chalcone based azacarboline analogues as novel antitubulin agents: Design, synthesis, biological evaluation and molecular modelling studies

    European Journal of Medicinal Chemistry1970journal article

    View DOI
    0 cites

  35. Cu(I)-catalyzed tandem decarboxylative/C-H activation coupling of cyclic diketones, proline and alkynes: Synthesis of α-alkynylated pyrrolidine-oxyindoles

    RSC Advances1970journal article

    View DOI
    0 cites

  36. Synthesis and evaluation of naphthoflavones as a new class of non purine xanthine oxidase inhibitors This Letter is dedicated to Dr. K. L. Dhar on the occasion of his 78th birthday.

    Bioorganic and Medicinal Chemistry Letters1970journal article

    View DOI
    0 cites

  37. Boric acid catalyzed Ugi three-component reaction in aqueous media

    RSC Advances1970journal article

    View DOI
    0 cites

  38. Hydroxamic acid derivatives as potential anticancer agents

    Hydroxamic Acids: A Unique Family of Chemicals with Multiple Biological Activities1970book

    View DOI
    0 cites

  39. Micelle promoted multicomponent synthesis of 3-amino alkylated indoles via a Mannich-type reaction in water

    RSC Advances1970journal article

    View DOI
    0 cites

  40. Modeling of LIM-kinase 2 inhibitory activity of pyrrolopyrimidine analogues: Useful in treatment of ocular hypertension and glaucoma

    Medicinal Chemistry1970journal article

    View DOI
    0 cites

  41. Nanoparticle catalyzed reaction (NPCR): ZnO-NP catalyzed Ugi-reaction in aqueous medium

    Green Chemistry1970journal article

    View DOI
    0 cites

  42. Structure activity relationship of arylidene pyrrolo and pyrido [2,1-b] quinazolones as cytotoxic agents: Synthesis, SAR studies, biological evaluation and docking studies

    Medicinal Chemistry1970journal article

    View DOI
    0 cites

  43. Synthesis of imine-pyrazolopyrimidinones and their mechanistic interventions on anticancer activity

    Bioorganic and Medicinal Chemistry1970journal article

    View DOI
    0 cites

  44. A catalyst-free C-H hydroarylation of coumarin derived ortho-quinone methide (o-QM) with electron rich arenes in glycerol

    RSC Advances1970journal article

    View DOI
    0 cites

  45. Catalyst-free hydroarylation of in situ generated ortho-quinone methide (o-QM) with electron rich arenes in water

    Green Chemistry1970journal article

    View DOI
    0 cites

  46. Colloidal carriers: A rising tool for therapy of tuberculosis

    Critical Reviews in Therapeutic Drug Carrier Systems1970journal article

    View DOI
    0 cites

  47. L-Proline catalysed multicomponent synthesis of 3-amino alkylated indoles via a Mannich-type reaction under solvent-free conditions

    Green Chemistry1970journal article

    View DOI
    0 cites

  48. Micelle promoted supramolecular carbohydrate scaffold-catalyzed multicomponent synthesis of 1,2-dihydro-1-aryl-3H-naphth[1,2-e][1,3]oxazin-3-one and amidoalkyl naphthols derivatives in aqueous medium

    RSC Advances1970journal article

    View DOI
    0 cites

  49. Synthesis of combretastatin analogs: Evaluation of in vitro anticancer activity and molecular docking studies

    Medicinal Chemistry Research1970journal article

    View DOI
    0 cites

  50. A rational approach for the design and synthesis of 1-acetyl-3,5-diaryl-4, 5-dihydro(1H)pyrazoles as a new class of potential non-purine xanthine oxidase inhibitors

    Bioorganic and Medicinal Chemistry1970journal article

    View DOI
    0 cites

  51. An efficient non-ionic surfactant catalyzed multicomponent synthesis of novel benzylamino coumarin derivative via Mannich type reaction in aqueous media

    Tetrahedron Letters1970journal article

    View DOI
    0 cites

  52. N-(1,3-Diaryl-3-oxopropyl)amides as a new template for xanthine oxidase inhibitors

    Bioorganic and Medicinal Chemistry1970journal article

    View DOI
    0 cites

  53. Possible role of epidermal growth factor receptors in the therapy of pancreatic cancer

    Critical Reviews in Therapeutic Drug Carrier Systems1970journal article

    View DOI
    0 cites

  54. Synthesis and antimicrobial evaluation of 3,5- pyrazolidine-dione substituted 4-quinolone derivatives

    International Journal of Drug Development and Research1970journal article

    0 cites

  55. Non-ionic surfactant catalyzed synthesis of Betti base in water

    Tetrahedron Letters1970journal article

    View DOI
    0 cites

  56. Synthesis and biological evaluation of arylidene analogues of Meldrum's acid as a new class of antimalarial and antioxidant agents

    Bioorganic and Medicinal Chemistry1970journal article

    View DOI
    0 cites

  57. An efficient organocatalyzed multicomponent synthesis of diarylmethanes via Mannich type Friedel-Crafts reaction

    Tetrahedron Letters1970journal article

    View DOI
    0 cites

  58. Fast-growing, non-infectious and intracellularly surviving drug-resistant Mycobacterium aurum: A model for high-throughput antituberculosis drug screening

    Journal of Antimicrobial Chemotherapy1970journal article

    View DOI
    0 cites

  59. Chemical structure indices in in silico molecular design

    Scientia Pharmaceutica1970journal article

    View DOI
    0 cites

  60. QSAR studies on benzoylaminobenzoic acid derivatives as inhibitors of β-ketoacyl-acyl carrier protein synthase III

    European Journal of Medicinal Chemistry1970journal article

    View DOI
    0 cites

  61. C-3 alkyl/arylalkyl-2,3-dideoxy hex-2-enopyranosides as antitubercular agents: Synthesis, biological evaluation, and QSAR study

    Journal of Medicinal Chemistry1970journal article

    View DOI
    0 cites

  62. A high dimensional QSAR study on the aldose reductase inhibitory activity of some flavones: Topological descriptors in modeling the activity

    Journal of Chemical Information and Modeling1970journal article

    View DOI
    0 cites

  63. Electronic surface features in modeling the protein farnesyltransferase inhibitory activity of tetrahydroquinoline analogues: A rational for the design of antimalarial agents

    Medicinal Chemistry Research1970journal article

    View DOI
    0 cites

  64. Topological descriptors in modeling the antimalarial activity of 4-(3′,5′-disubstituted anilino)quinolines

    Journal of Chemical Information and Modeling1970journal article

    View DOI
    0 cites

  65. 2D-QSAR in hydroxamic acid derivatives as peptide deformylase inhibitors and antibacterial agents

    Bioorganic and Medicinal Chemistry1970journal article

    View DOI
    0 cites