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N. S. Hari Narayana Moorthy

Indira Gandhi National Tribal UniversityIN
ORCID0000-0003-2300-4074
h-index
29

via OpenAlex

Citations
3,112

via OpenAlex

Publications
189

About

N. S. Hari Narayana Moorthy is a researcher at Indira Gandhi National Tribal University. With a research focus on computational chemistry and pharmacoinformatics, Moorthy has published 89 papers over the span of 1970 to 2020, covering topics such as QSAR modeling, machine learning, and structure-activity relationships.

Research areas

  • Chemistry
  • Stereochemistry
  • Biochemistry
  • Organic chemistry
  • Biology

Publications (189)

Sorted by most cited.

  1. Xanthan gum derivatives: review of synthesis, properties and diverse applications

    2020

    View DOI
    315 cites
  2. Advances in Chalcones with Anticancer Activities

    2014

    View DOI
    278 cites
  3. Recent Advances in Protein Tyrosine Phosphatase 1B Targeted Drug Discovery for Type II Diabetes and Obesity

    2017

    View DOI
    71 cites
  4. Viral M2 Ion Channel Protein: A Promising Target for Anti-influenza Drug Discovery

    2014

    View DOI
    69 cites
  5. The Rise and Fall of Chloroquine/Hydroxychloroquine as Compassionate Therapy of COVID-19

    2021

    View DOI
    66 cites
  6. Aryl- and Heteroaryl-Thiosemicarbazone Derivatives and Their Metal Complexes: A Pharmacological Template

    2013

    View DOI
    59 cites
  7. 6H-Indolo[2,3-b]Quinoxalines: DNA and Protein Interacting Scaffold for Pharmacological Activities

    2013

    View DOI
    54 cites
  8. Synthesis of Some Coumarinyl Chalcones and their Antiproliferative Activity Against Breast Cancer Cell Lines

    2011

    View DOI
    45 cites
  9. 41 cites
  10. Design, synthesis and biological evaluation of some novel 3-cinnamoyl-4-hydroxy-2H-chromen-2-ones as antimalarial agents

    Medicinal Chemistry Research1970journal article

    View DOI
    39 cites
  11. Microwave-Assisted Functionalization of Multi-Walled Carbon Nanotubes for Biosensor and Drug Delivery Applications

    2023

    View DOI
    38 cites
  12. Recent Advances in the Development of Fatty Acid Synthase Inhibitors as Anticancer Agents

    2020

    View DOI
    35 cites
  13. Synthesis and Characterization of Some Chalcone Derivatives

    2007

    View DOI
    34 cites
  14. QSAR analysis of 2-benzoxazolyl hydrazone derivatives for anticancer activity and its possible target prediction

    Medicinal Chemistry Research1970journal article

    View DOI
    34 cites
  15. Repaglinide-laden hydrogel particles of xanthan gum derivatives for the management of diabetes

    2022

    View DOI
    31 cites
  16. Classification of carcinogenic and mutagenic properties using machine learning method

    2017

    View DOI
    30 cites
  17. Lysinated Multiwalled Carbon Nanotubes with Carbohydrate Ligands as an Effective Nanocarrier for Targeted Doxorubicin Delivery to Breast Cancer Cells

    2022

    View DOI
    29 cites
  18. Human Ether-a-Go-Go-Related Gene Channel Blockers and its Structural Analysis for Drug Design

    2013

    View DOI
    29 cites
  19. Ligand-conjugated multiwalled carbon nanotubes for cancer targeted drug delivery

    2024

    View DOI
    28 cites
  20. lH-Pyrazolo[3,4-b]quinolin-3-amine derivatives inhibit growth of colon cancer cells via apoptosis and sub G1 cell cycle arrest

    2018

    View DOI
    28 cites
  21. Comparative studies on conventional and microwave assisted synthesis of benzimidazole and their 2-substituted derivative with the effect of salt form of reactant

    Chemical & Pharmaceutical Bulletin1970journal article

    View DOI
    28 cites
  22. Design and discovery of silybin analogues as antiproliferative compounds using a ring disjunctive – Based, natural product lead optimization approach

    2017

    View DOI
    27 cites
  23. Design, synthesis and biological evaluation of some tetrazole acetamide derivatives as novel non-carboxylic PTP1B inhibitors

    2019

    View DOI
    24 cites
  24. Ligand based analysis on HMG-CoA reductase inhibitors

    2014

    View DOI
    24 cites
  25. QSAR modelling of HIV-1 reverse transcriptase inhibition by benzoxazinones using a combination of P_VSA and pharmacophore feature descriptors

    Bioorganic & Medicinal Chemistry Letters1970journal article

    View DOI
    24 cites
  26. Design, synthesis, cytotoxic evaluation, and QSAR study of some 6H-indolo[2,3-b]quinoxaline derivatives

    Journal of Enzyme Inhibition and Medicinal Chemistry1970journal article

    View DOI
    24 cites
  27. Fused Aryl-Phenazines: Scaffold for the Development of Bioactive Molecules

    2014

    View DOI
    22 cites
  28. Structural feature study of benzofuran derivatives as farnesyltransferase inhibitors

    Journal of Enzyme Inhibition and Medicinal Chemistry1970journal article

    View DOI
    21 cites
  29. Synthesis and biological evaluation of some N-(3-(1H-tetrazol-5-yl) phenyl)acetamide derivatives as novel non-carboxylic PTP1B inhibitors designed through bioisosteric modulation

    2018

    View DOI
    18 cites
  30. Classification study of solvation free energies of organic molecules using machine learning techniques

    2014

    View DOI
    18 cites
  31. Topological, hydrophobicity, and other descriptors on α-glucosidase inhibition: a QSAR study on xanthone derivatives

    2011

    View DOI
    17 cites
  32. Prediction of the relationship between the structural features of andrographolide derivatives and alpha-glucosidase inhibitory activity: A quantitative structure-activity relationship (QSAR) Study

    Journal of Enzyme Inhibition and Medicinal Chemistry1970journal article

    View DOI
    17 cites
  33. Synthesis, antifungal evaluation and in silico study of novel Schiff bases derived from 4-amino-5(3,5-dimethoxy-phenyl)-4H-1,2,4-triazol-3-thiol

    2014

    View DOI
    16 cites
  34. QSAR Analysis of Isosteviol Derivatives as α-Glucosidase Inhibitors with Element Count and Other Descriptors

    2010

    View DOI
    16 cites
  35. A new approach for PEGylation of dendrimers

    Bioorganic & Medicinal Chemistry Letters1970journal article

    View DOI
    16 cites
  36. QSAR analysis of some phthalimide analogues based inhibitors of HIV-1 integrase

    2007

    View DOI
    15 cites
  37. In Silico-Based Structural Analysis of Arylthiophene Derivatives for FTase Inhibitory Activity, hERG, and Other Toxic Effects

    Journal of Biomolecular Screening1970journal article

    View DOI
    15 cites
  38. QSAR analysis of some 5-amino-2-mercapto-1,3,4-thiadiazole based inhibitors of matrix metalloproteinases and bacterial collagenase

    Bioorganic & Medicinal Chemistry Letters1970journal article

    View DOI
    15 cites
  39. The KNIME based classification models for yellow fever virus inhibition

    2015

    View DOI
    14 cites
  40. Synthesis and Physicochemical Characterization of Mutual Prodrug of Indomethacin

    2007

    View DOI
    14 cites
  41. Comparative Structural Analysis of a-Glucosidase Inhibitors on Difference Species: A Computational Study

    Archiv Der Pharmazie1970journal article

    View DOI
    14 cites
  42. COMPARATIVE STUDY OF FORCED DEGRADATION BEHAVIOR OF PRASUGREL BY UPLC AND HPLC AND THE DEVELOPMENT OF VALIDATED STABILITY INDICATING ASSAY METHOD

    Journal of Liquid Chromatography & Related Technologies1970journal article

    View DOI
    14 cites
  43. Curcumin coating: a novel solution to mitigate inherent carbon nanotube toxicity

    2024

    View DOI
    12 cites
  44. Antiproliferative Efficacy of N-(3-chloro-4-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine, DW-8, in Colon Cancer Cells Is Mediated by Intrinsic Apoptosis

    2021

    View DOI
    11 cites
  45. Fatty Acid Synthase (FASN): A Patent Review Since 2016-Present

    2023

    View DOI
    10 cites
  46. A Novel Dialkylamino-Functionalized Chalcone, DML6, Inhibits Cervical Cancer Cell Proliferation, In Vitro, via Induction of Oxidative Stress, Intrinsic Apoptosis and Mitotic Catastrophe

    2021

    View DOI
    10 cites
  47. Multi-algorithm based machine learning and structural pattern studies for hERG ion channel blockers mediated cardiotoxicity prediction

    2020

    View DOI
    10 cites
  48. Molecular dynamic simulations and structure-based pharmacophore development for farnesyltransferase inhibitors discovery

    2016

    View DOI
    10 cites
  49. A new simple and rapid validated RP-HPLC method for determination of ziprasidone in ziprasidone capsules

    2012

    View DOI
    10 cites
  50. Analysis of the α-Glucosidase Inhibitory Activity of Chromenone Derivatives Based on their Molecular Features: A Computational Study

    2011

    View DOI
    10 cites
  51. Quantitative Structure-Activity Relationships of Selective Antagonists of Glucagon Receptor Using QuaSAR Descriptors

    2006

    View DOI
    10 cites
  52. Design, synthesis, and anticancer activity of some novel 1H-benzo[d]imidazole-5-carboxamide derivatives as fatty acid synthase inhibitors

    2023

    View DOI
    9 cites
  53. Synthesis and Anti-microbial Evaluation of Some 3, 4-Dihydro Pyrimidine-2-one Derivatives

    2008

    View DOI
    9 cites
  54. Classification analysis of fatty acid synthase inhibitors using multialgorithms on topological descriptors and structural fingerprints

    2022

    View DOI
    8 cites
  55. Use of lysinated multiwalled carbon nanotubes with carbohydrate ligands as a doxorubicin nanocarrier: A molecular dynamics analysis

    2023

    View DOI
    7 cites
  56. Novel 3-((2-chloroquinolin-3-yl)methylene)indolin-2-one derivatives produce anticancer efficacy in ovarian cancer in vitro

    2019

    View DOI
    7 cites
  57. Development and validation of a RP-HPLC method for determination of citicoline monosodium in human plasma

    2011

    7 cites
  58. QSAR studies of cytotoxic acridine 5,7-diones : A comparative study using P-VSA descriptors and topological descriptors

    2007

    7 cites
  59. QSAR Modeling of Some 2-methoxy Acridones: Cytotoxic Agents in Multi Drug Resistant Cells

    2006

    View DOI
    7 cites
  60. Structural analysis of structurally diverse alpha-glucosidase inhibitors for active site feature analysis

    Journal of Enzyme Inhibition and Medicinal Chemistry1970journal article

    View DOI
    7 cites
  61. Theranostics Inorganic Nano-particles for Brain Tumor Diagnosis and Treatment

    2023

    View DOI
    6 cites
  62. Dual mechanism of HIV-1 integrase and RNase H inhibition by diketo derivatives – a computational study

    2014

    View DOI
    6 cites
  63. Insulin like Growth Factor-1 Receptor: An Anticancer Target Waiting for Hit

    2006

    View DOI
    6 cites
  64. Synthesis, in silico metabolic and toxicity prediction of some novel imidazolinones derivatives as potent anticonvulsant agents

    Journal of Enzyme Inhibition and Medicinal Chemistry1970journal article

    View DOI
    6 cites
  65. Anti-colorectal Cancer Activity of Quinazoline Derivatives: A ComprehensiveReview

    2023

    View DOI
    5 cites
  66. Design, Synthesis and Biological Evaluation of 3-(2-(benzo[d]thiazol-2- ylthio)acetamido)benzoic Acid Derivatives as Inhibitors of Protein Tyrosine Phosphatase 1B

    2020

    View DOI
    5 cites
  67. QSAR studies and molecular shape analysis of azonafide derivatives as topoisomerase II inhibitors

    2003

    5 cites
  68. Novel isatin-chalcone molecular hybrids endowed with potent antistaphylococcal properties: In vitro and mechanistic insights

    2026

    View DOI
    4 cites
  69. Metabolite profiling, antimalarial potentials of Schleichera oleosa using LC-MS and GC-MS: in vitro, molecular docking and molecular dynamics

    2025

    View DOI
    4 cites
  70. In silico-guided discovery and in vitro validation of novel sugar-tethered lysinated carbon nanotubes for targeted drug delivery of doxorubicin

    2024

    View DOI
    4 cites
  71. Ascendancy of <scp>pH</scp>‐irresponsive Moi gum in the design of modified xanthan gum semi‐interpenetrating network hydrogels for monitoring diabetes

    2022

    View DOI
    4 cites
  72. Structure based virtual screening of natural product molecules as glycosidase inhibitors

    2021

    View DOI
    4 cites
  73. Xanthan-based nanomaterials for drug delivery applications

    2021

    View DOI
    4 cites
  74. QSAR and Pharmacophore Analysis of a Series of Piperidinyl Urea Derivatives as hERG Blockers and H3 Antagonists

    2013

    View DOI
    4 cites
  75. Synthesis, Biological Evaluation and in silico Metabolic and Toxicity Prediction of Some Flavanone Derivatives.

    2007

    View DOI
    4 cites
  76. AIDS: A review of targets and approaches for treatment

    2007

    View DOI
    4 cites
  77. QSAR Studies on Some GSK-3α Inhibitory 6-aryl-pyrazolo (3,4-b) pyridines

    2006

    View DOI
    4 cites
  78. Modeling VEGFR kinase inhibition of aminopyrazolopyridine urea derivatives using topological and physicochemical descriptors: a quantitative structure activity analysis study

    Medicinal Chemistry Research1970journal article

    View DOI
    4 cites
  79. Design, synthesis, and pharmacological evaluation of heteroaryl thiol-linked kojic acid derivatives as a novel class of acetylcholinesterase inhibitors for Alzheimer’s disease therapy

    2025

    View DOI
    3 cites
  80. Synthesis and evaluation of some amino acid conjugates of suprofen

    2012

    View DOI
    3 cites
  81. Synthesis and evaluation of some amino acid conjugates of pirprofen

    2012

    View DOI
    3 cites
  82. Synthesis, Biological Evaluation and QSPR Studies ofAmino Acid Conjugates of Cinmetacin

    2007

    View DOI
    3 cites
  83. Simultaneous spectrophotometric methods for the estimation of nimesulide and tizanidine in a tablet dosage form

    2005

    3 cites
  84. In Silico Based Structural and Fingerprint Analysis of Structurally Diverse AT1 inhibitors

    2020

    View DOI
    2 cites
  85. Quantitative Structure Activity Relationship Analysis of Some Diarylsulphonylurea Derivatives as Tubulin Binding Agents

    2007

    View DOI
    2 cites
  86. Targeted Delivery of Doxorubicin to Breast Cancer Cells by Multiwalled Carbon Nanotubes Functionalized with Lysine via 1,3-Dipolar Cycloaddition and Conjugation with Sugar Moieties

    2022

    View DOI
    1 cites
  87. Targeting Angiotensin-converting Enzyme 2 (ACE2) for the Discovery of Anticoronaviral Drugs

    2022

    View DOI
    1 cites
  88. Virtual Screening Based Discovery of PTP1B Inhibitors and Their Biological Evaluations

    2020

    View DOI
    1 cites
  89. Binding mode of conformations and structure-based pharmacophore development for farnesyltransferase inhibitors

    2016

    View DOI
    1 cites
  90. Human Ether-a-Go-Go-Related Gene Channel Blockers and its Structural Analysis for Drug Design

    2012

    View DOI
    1 cites
  91. Determination of salmeterol xinafoate and its degradation products according to ICH guidelines with use of UPLC technique

    2011

    1 cites
  92. RP-HPLC method for simultaneous estimation of amlodipine and valsartan in tablet formulation and validation as per ICH guidelines

    2011

    1 cites
  93. QSAR Analysis of HIV-1 Reverse Transcriptase Inhibitory 5-Alkyl-2- [(Aryl and Alkyloxylcarbonylmethyl)Thio]-6- (1-Napthylmethyl) Pyrimidin-4 (3H)-Ones*

    2010

    View DOI
    1 cites
  94. Pharmacological Evaluation of Different Extract of Asclepias daemia Leaves

    2007

    View DOI
    1 cites
  95. Quantitative structure activity analysis of 2-alkoxydihydrocinnamates as PPAR alpha/gamma dual agonist

    Medicinal Chemistry1970journal article

    View DOI
    1 cites
  96. Investigation of plant-derived compounds as potent inhibitors of casein kinase-1 alpha through computational analysis and molecular dynamic simulations

    2026

    View DOI
    0 cites
  97. Synthesis, Biological evaluation, and computational study of 2-((2-oxo-2-(arylamino)ethyl)thio)-1H-benzo[d]imidazole-5-carboxylic acids as PTP1B inhibitors for the treatment of type 2 diabetes

    2026

    View DOI
    0 cites
  98. Identification and Mechanistic Profiling of Indolin‐2‐One Derivatives That Induce ROS‐Driven Intrinsic Apoptosis in Prostate and Colorectal Cancer Cells

    2025

    View DOI
    0 cites
  99. Design, synthesis and biological evaluation of 2-phenylquinoxaline carbonyl piperazine derivatives as novel FASN inhibitors with anticancer activity

    2025

    View DOI
    0 cites
  100. Ligand based analysis of the solubility of drugs using in silico techniques

    2025

    View DOI
    0 cites
  101. Machine learning-based analysis on retention time of pesticides for eco-friendly and cost-effective analytical method development

    2025

    View DOI
    0 cites
  102. List of contributors

    2024

    View DOI
    0 cites
  103. Exploring material and metals for antimicrobial nanocoatings

    2024

    View DOI
    0 cites
  104. Design, Synthesis and Biological Evaluation of Novel 1H-benzo[d]imidazole Derivatives as Fatty Acid Synthase (FASN) Inhibitors for Cancer Treatment

    2022

    View DOI
    0 cites
  105. Molecular Dynamic Simulations-Based Conformational Analysis and Binding Study of CP-225917 on Farnesyl Transferase Enzyme

    2022

    View DOI
    0 cites
  106. Review for "Solubility and swelling of soils from native starch"

    2022

    View DOI
    0 cites
  107. Synthesis, biological evaluation and molecular docking studies of 4-arylidene-2-phenyloxazol-5(4H)-one derivatives as inhibitors of dual-specificity tyrosine phosphorylation-regulated kinases and Cdc2-like kinases

    2021

    View DOI
    0 cites
  108. Contributors

    2021

    View DOI
    0 cites
  109. Plant derived active compounds as potential anti SARS-CoV-2 agents: an <i>in-silico</i> study

    2021

    View DOI
    0 cites
  110. Binding Mode Prediction and Identification of New Lead Compounds from Natural Products as 3-OST Enzyme Inhibitors

    2020

    View DOI
    0 cites
  111. Natural Products in Clinical Trials

    2018

    0 cites
  112. Apoptosis Targeting Therapeutics in Clinical Trials

    2016

    View DOI
    0 cites
  113. Synthesis, characterization and biological evaluation of N-(5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl)-4-nitrobenzamide derivatives

    2015

    0 cites
  114. Anticancer activities of chalcones: A review on patent perspective

    Recent Patents in Anticancer Drug Discovery2014journal article

    0 cites
  115. Dual Mechanism of HIV-1 Integrase and RNase H Inhibition by Diketo Derivatives: A computational study.

    RSC Advances2014journal article

    0 cites
  116. Fused aryl-phenazines: Scaffold for the development of bioactive molecules.

    Current Drug Targets2014journal article

    0 cites
  117. Synthesis, Antifungal Evaluation and In silico Study of Novel Schiff Bases Derived from 4-amino-5(3,5-dimethoxy-phenyl)-4H-1,2,4-triazol-3-thiol.

    Arabian Journal of Chemistry2014journal article

    View DOI
    0 cites
  118. A new simple and rapid validated RP-UPLC method for determination of ziprasidone in ziprasidone capsules.

    Journal of Saudi Chemical Society2014journal article

    View DOI
    0 cites
  119. Farnesyltransferase Inhibitors: A Comprehensive Review Based on Quantitative Structural Analysis

    Current Medicinal Chemistry2013journal article

    0 cites
  120. Iconography : Synthesis and evaluation of some amino acid conjugates of suprofen

    2013

    0 cites
  121. Structurally modified celecoxib analogues for selective COX-2 inhibition: a classical hansch QSAR approach

    2012

    0 cites
  122. Study of forced degradation behaviour of eprosartan mesylate and development of validated stability indicating assay method by UPLC

    2011

    0 cites
  123. RP-HPLC method for estimation and stability study of drotaverine HCl as per ICH guidelines

    2011

    0 cites
  124. ChemInform Abstract: Iodine‐Catalyzed, One‐Pot, Solid‐Phase Synthesis of Benzothiazole Derivatives.

    2008

    View DOI
    0 cites
  125. QSAR Studies of 6‐Amino Uracil Base Analogues: A Thymidine Phosphorylase Inhibitor in Cancer Therapy

    2007

    View DOI
    0 cites
  126. 6H-Indolo[2,3-b]Quinoxalines: DNA and Protein Interacting Scaffold for Pharmacological Activities

    Mini-Reviews in Medicinal Chemistry1970journal article

    0 cites
  127. Determination of Salmeterol Xinafoate and its Degradation Products According to ICH Guidelines with use of UPLC Technique

    Latin American Journal of Pharmacy1970journal article

    0 cites
  128. QSAR Analysis of Isosteviol Derivatives as alpha-Glucosidase Inhibitors with Element Count and Other Descriptors

    Letters in Drug Design & Discovery1970journal article

    0 cites
  129. Topological, hydrophobicity, and other descriptors on alpha-glucosidase inhibition: a QSAR study on xanthone derivatives

    Journal of Enzyme Inhibition and Medicinal Chemistry1970journal article

    View DOI
    0 cites
  130. QSAR analysis of 5,6-dihydro-4-hydroxy-2-pyrone analogues: HIV-1 protease inhibitor

    Asian Journal of Chemistry1970journal article

    0 cites
  131. QSAR study of anticancer agents: 1,8-Naphthyridine derivatives

    Asian Journal of Chemistry1970journal article

    0 cites
  132. DNA fingerprinting: A prophecy fulfilled

    Pharma Times1970journal article

    0 cites
  133. 0 cites
  134. QSAR modeling of some 2-methoxy acridones: Cytotoxic in multi drug resistant cells

    International Journal of Cancer Research1970journal article

    0 cites
  135. QSAR studies of 2-aroylindole derivatives: Tubulin inhibitors in cancer therapy

    Asian Journal of Chemistry1970journal article

    0 cites
  136. QSAR studies of anti-malarial agents: 2,4-Diamino pyrimidine derivatives

    Asian Journal of Chemistry1970journal article

    0 cites
  137. Quantitative structure - Activity relationships of selective antagonists of glucagon receptor using QuaSAR descriptors

    Chemical & Pharmaceutical Bulletin1970journal article

    0 cites
  138. 0 cites
  139. QSAR studies and molecular shape analysis of azonafide derivatives as topoisomerase II inhibitors

    Indian Journal of Pharmaceutical Sciences1970journal article

    0 cites