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Ponnurengam Malliappan Sivakumar

University of PisaIN
ORCID0000-0002-5880-9596
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27

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Citations
2,253

via OpenAlex

Publications
107

About

Ponnurengam Malliappan Sivakumar is a researcher at the University of Pisa, with a sustained publication record spanning over five decades. He has contributed significantly to the fields of QSAR studies, antimicrobial agents, and biodegradable composites, as evident from his numerous publications in journals such as Chemical and Pharmaceutical Bulletin, Bioorganic and Medicinal Chemistry Letters, Journal of Chemistry, and others.

Research areas

  • Chemistry
  • Materials science
  • Biology
  • Organic chemistry
  • Biochemistry

Publications (107)

Sorted by most cited.

  1. QSAR Studies on chalcones and flavonoids as anti-tuberculosis agents using genetic function approximation (GFA) method

    Chemical and Pharmaceutical Bulletin1970journal article

    View DOI
    144 cites

  2. Synthesis, antioxidant evaluation, and quantitative structure-activity relationship studies of chalcones

    Medicinal Chemistry Research1970journal article

    View DOI
    144 cites

  3. Bone tissue engineering: Anionic polysaccharides as promising scaffolds

    2022

    View DOI
    139 cites

  4. Synthesis, antimycobacterial activity evaluation, and QSAR studies of chalcone derivatives

    Bioorganic and Medicinal Chemistry Letters1970journal article

    View DOI
    111 cites

  5. Novel chalcones and 1,3,5-triphenyl-2-pyrazoline derivatives as antibacterial agents

    Chemical Biology and Drug Design1970journal article

    View DOI
    97 cites

  6. Effective antibacterial adhesive coating on cotton fabric using ZnO nanorods and chalcone

    Carbohydrate Polymers1970journal article

    View DOI
    95 cites

  7. Synthesis, antibacterial activity evaluation and QSAR studies of novel dispiropyrrolidines

    2010

    View DOI
    90 cites

  8. Synthesis of magnesium phosphate nanoflakes and its PCL composite electrospun nanofiber scaffolds for bone tissue regeneration

    Materials Science and Engineering C1970journal article

    View DOI
    75 cites

  9. Synthesis, biological evaluation, mechanism of action and quantitative structure-activity relationship studies of chalcones as antibacterial agents

    Chemical Biology and Drug Design1970journal article

    View DOI
    67 cites

  10. Near infra-red polymeric nanoparticle based optical imaging in Cancer diagnosis

    Journal of Photochemistry and Photobiology B: Biology1970journal article

    View DOI
    57 cites

  11. Antifungal activity, mechanism and QSAR studies on chalcones

    Chemical Biology and Drug Design1970journal article

    View DOI
    55 cites

  12. Fuzzy Drug Targets: Disordered Proteins in the Drug-Discovery Realm

    ACS Omega2023journal article

    View DOI
    54 cites

  13. Polysaccharide-bioceramic composites for bone tissue engineering: A review

    2023

    View DOI
    52 cites

  14. Design of a papain immobilized antimicrobial food package with curcumin as a crosslinker

    PLoS ONE1970journal article

    View DOI
    52 cites

  15. Improved Analgesic and Anti-Inflammatory Effect of Diclofenac Sodium by Topical Nanoemulgel: Formulation Development—In Vitro and In Vivo Studies

    Journal of Chemistry2020journal article

    View DOI
    49 cites

  16. Experimental and QSAR of acetophenones as antibacterial agents

    Chemical Biology and Drug Design1970journal article

    View DOI
    47 cites

  17. Novel 1,3,5-triphenyl-2-pyrazolines as anti-infective agents

    Bioorganic and Medicinal Chemistry Letters1970journal article

    View DOI
    43 cites

  18. Design of antimicrobial polycaprolactam nanocomposite by immobilizing subtilisin conjugated Au/Ag core-shell nanoparticles for biomedical applications

    Materials Science and Engineering C1970journal article

    View DOI
    41 cites

  19. Protein tyrosine phosphatase 1b inhibitors: A novel therapeutic strategy for the management of type 2 diabetes mellitus

    Current Pharmaceutical Design1970journal article

    View DOI
    40 cites

  20. Green synthesis of protein stabilized silver nanoparticles using Pseudomonas fluorescens, a marine bacterium, and its biomedical applications when coated on polycaprolactam

    Industrial and Engineering Chemistry Research1970journal article

    View DOI
    39 cites

  21. Immobilization of subtilisin on polycaprolactam for antimicrobial food packaging applications

    Journal of Agricultural and Food Chemistry1970journal article

    View DOI
    37 cites

  22. 3′-Hydroxy-4-methoxychalcone as a potential antibacterial coating on polymeric biomaterials

    Applied Surface Science1970journal article

    View DOI
    35 cites

  23. Molecular Dynamics Simulations in Drug Discovery and Drug Delivery

    2020

    View DOI
    34 cites

  24. Antibiofilm properties of interfacially active lipase immobilized porous polycaprolactam prepared by LB technique

    PLoS ONE1970journal article

    View DOI
    32 cites

  25. Antibacterial activity and QSAR of chalcones against biofilm-producing bacteria isolated from marine waters

    SAR and QSAR in Environmental Research1970journal article

    View DOI
    32 cites

  26. Isolation and characterization of agro-waste biomass sapodilla seeds as reinforcement in potential polymer composite applications

    2023

    View DOI
    31 cites

  27. 2-Methoxy-2',4'-dichloro chalcone as an antimicrofoulant against marine bacterial biofilm

    Colloids and Surfaces B: Biointerfaces1970journal article

    View DOI
    29 cites

  28. Development, Optimization, and Evaluation of Luliconazole Nanoemulgel for the Treatment of Fungal Infection

    2021

    View DOI
    27 cites

  29. Chalcone embedded polyurethanes as a biomaterial: Synthesis, characterization and antibacterial adhesion

    Carbohydrate Polymers1970journal article

    View DOI
    25 cites

  30. Expeditious synthesis, antibacterial activity evaluation and GQSAR studies of 3-bisoxindoles, 2-oxindolyl-2-hydroxyindan-1,3-diones and 2-oxindolyl-2-hydroxyacenaphthylen-1-ones

    RSC Advances1970journal article

    View DOI
    23 cites

  31. The circadian rhythm: an influential soundtrack in the diabetes story

    2023

    View DOI
    21 cites

  32. Impact of topological and electronic descriptors in the QSAR of pyrazine containing thiazolines and thiazolidinones as antitubercular and antibacterial agents

    Chemical Biology and Drug Design1970journal article

    View DOI
    20 cites

  33. Enhanced properties of nickel–silver codoped hydroxyapatite for bone tissue engineering: Synthesis, characterization, and biocompatibility evaluation

    2023

    View DOI
    19 cites

  34. A simple protocol for the michael addition of indoles with electron deficient olefins catalysed by TBAHS in aqueous media and their broad spectrum antibacterial activity

    2009

    View DOI
    19 cites

  35. Chalcone coating on cotton cloth-an approach to reduce attachment of live microbes

    Biomaterials Science1970journal article

    View DOI
    19 cites

  36. Molecular Insights on the Therapeutic Effect of Selected Flavonoids on Diabetic Neuropathy

    2022

    View DOI
    18 cites

  37. Combustion Characteristics of Nanoaluminium-Based Composite Solid Propellants: An Overview

    Journal of Chemistry2021journal article

    View DOI
    18 cites

  38. Antibacterial activity, quantitative structure-activity relationship and diastereoselective synthesis of isoxazolidine derivatives via 1,3-dipolar cycloaddition of d-glucose derived nitrone with olefin

    Chemical Biology and Drug Design1970journal article

    View DOI
    18 cites

  39. Development of Polymer and Surfactant Based Naringenin Nanosuspension for Improvement of Stability, Antioxidant, and Antitumour Activity

    Journal of Chemistry2020journal article

    View DOI
    17 cites

  40. Synthesis, characterization of novel silicotungstic acid incorporated SPEEK/PVA-co-ethylene-based composite membranes for fuel cell

    Journal of Materials Science1970journal article

    View DOI
    17 cites

  41. Enhanced Targeted Delivery of Minocycline via Transferrin Conjugated Albumin Nanoparticle Improves Neuroprotection in a Blast Traumatic Brain Injury Model

    2023

    View DOI
    16 cites

  42. Current Trends in the Therapeutic Strategies for Diabetes Management

    Current Medicinal Chemistry2021journal article

    View DOI
    16 cites

  43. Electrospun silk fibroin and gelatin blended nanofibers functionalized with noble metal nanoparticles for enhanced biomedical applications

    2022

    View DOI
    15 cites

  44. Cyclodextrin-Based Nanosystems as Drug Carriers for Cancer Therapy

    2019

    View DOI
    15 cites

  45. A Review on Cassava Residues as Adsorbents for Removal of Organic and Inorganic Contaminants in Water and Wastewater

    Journal of Chemistry2023journal article

    View DOI
    14 cites

  46. An Insight into the Polymeric Nanoparticles Applications in DiabetesDiagnosis and Treatment

    2021

    View DOI
    14 cites

  47. Functionalized polycaprolactam as an active food package for antibiofilm activity and extended shelf life

    Colloids and Surfaces B: Biointerfaces1970journal article

    View DOI
    14 cites

  48. Phytochemical and Antioxidant Analysis of Bioactive Compound Extract from Nelumbo nucifera against Cancer Proteins: In Silico Spectroscopic Approach

    2025

    View DOI
    13 cites

  49. Identification of novel DNA gyrase inhibitor by combined pharmacophore modeling, QSAR analysis, molecular docking, molecular dynamics, ADMET and DFT approaches

    2024

    View DOI
    13 cites

  50. Role of GLP-1 Analogs in the Management of Diabetes and its SecondaryComplication

    2021

    View DOI
    13 cites

  51. QSAR studies on substituted 3- or 4-phenyl-1,8-naphthyridine derivatives as antimicrobial agents

    Medicinal Chemistry Research1970journal article

    View DOI
    13 cites

  52. Curcumin nanoparticles impregnated collagen/demineralized bone matrix/olive leaves extract biocomposites as a potential bone implant: Preparation, characterization, and biocompatibility

    2023

    View DOI
    11 cites

  53. Electrospun Silk Fibroin and Collagen Composite Nanofiber Incorporated with Palladium and Platinum Nanoparticles for Wound Dressing Applications

    2024

    View DOI
    8 cites

  54. Improving the Performance and Biodegradability of Biocomposites Made from Banana Sap and Banana Fibres

    Journal of Chemistry2024journal article

    View DOI
    8 cites

  55. Novel short Agave americana based biocomposite and nanobiocomposites for automotive applications

    2024

    View DOI
    7 cites

  56. Nanoemulsions: A Better Approach for Antidiabetic Drug Delivery

    2020

    View DOI
    7 cites

  57. Polymer-Graphene Nanoassemblies and their Applications in Cancer Theranostics

    2019

    View DOI
    7 cites

  58. Novel microarrays for simultaneous serodiagnosis of multiple antiviral antibodies

    PLoS ONE1970journal article

    View DOI
    7 cites

  59. Production Of Hydrogen By Anion Exchange Membrane Using AWE

    2014

    6 cites

  60. Current state and potential of polymersomes as ocular drug delivery systems

    2025

    View DOI
    5 cites

  61. Fabrication of Drug-Loaded Calcium Phosphate Nanoparticles: An Investigation of Microbial Toxicity

    2021

    View DOI
    5 cites

  62. Synthesis And Evaluation Of Antiinflammatory Activity Of Ibuprofen Analogs

    1999

    5 cites

  63. Gut Microbiota and Diabetes: Pioneering New Treatment Frontiers

    2025

    View DOI
    4 cites

  64. Antiproliferative Effect of Gallic Acid is Mediated via Mitochondrial‐ or ER‐Stress‐Induced Apoptosis and Canonical Autophagy in HT‐29 Cells

    Journal of Chemistry2024journal article

    View DOI
    4 cites

  65. Anti-inflammatory and analgesic effects of <i>Careya arborea</i> stem bark in experimental animal models

    2006

    View DOI
    4 cites

  66. Antithyroid agents and QSAR studies: Inhibition of lactoperoxidase- catalyzed iodination reaction by isochromene-1-thiones

    Medicinal Chemistry Research1970journal article

    View DOI
    4 cites

  67. Antibacterial Activities of 4-Substituted-2-[(E)-{(1S,2R)/(1R,2S)-1-Hydroxy-1-Phenylpropan-2-Ylimino}Methyl]Phenol

    Chemical Biology and Drug Design1970journal article

    View DOI
    4 cites

  68. QSAR and docking studies on propenone derivatives as dual COX and 5-LOX inhibitors

    Letters in Organic Chemistry1970journal article

    View DOI
    3 cites

  69. Polysaccharide-functionalized gold, silver, and iron oxide nanoparticles for siRNA delivery: The role of artificial intelligence in design and optimization

    2026

    View DOI
    2 cites

  70. Enzyme evolution and antioxidant defense in salt-stressed Kunthali rice: A pathway to sustainable biocatalytic solutions for crop improvement

    2025

    View DOI
    2 cites

  71. Advances in phototheranostic agents: From imaging to targeted therapy

    2025

    View DOI
    2 cites

  72. Anionic polysaccharides as delivery carriers for cancer therapy and theranostics: An overview of significance

    2024

    View DOI
    2 cites

  73. Editorial: Advanced approaches in the diagnosis and treatment of diabetes mellitus and secondary complications

    2023

    View DOI
    2 cites

  74. Computational approaches to improve aggrecanase-1 inhibitory activity of (4-keto) phenoxy) methyl biphenyl-4-sulfonamide: Group based QSAR and docking studies

    Medicinal Chemistry1970journal article

    View DOI
    2 cites

  75. Phytochemical and antioxidant analysis of bioactive compound extract from Nelumbo nucifera against cancer proteins: in silico spectroscopic approach

    2024

    View DOI
    1 cites

  76. Design and Synthesis of Photoreactive Polymers for Biomedical Applications

    2013

    View DOI
    1 cites

  77. Computational approaches to enhance activity of taxanes as antimitotic agent

    Medicinal Chemistry Research1970journal article

    View DOI
    1 cites

  78. Quantitative structure-activity relationships for commercially available inhibitors of COX-2

    Medicinal Chemistry1970journal article

    View DOI
    1 cites

  79. Graph-theoretic and computational analysis of QSAR molecular descriptors for single chain diamond silicates

    2025

    View DOI
    0 cites

  80. Explore the risk perception and evaluate the effectiveness of competency-based intervention (CBI) on knowledge and lifestyle changes among type 2 diabetes mellitus patients.

    2023

    View DOI
    0 cites

  81. Photoreactive polymers for microarray chips

    2015

    0 cites

  82. Photoreactive Polymers For Microarray Chips

    2014

    View DOI
    0 cites

  83. Analgesic and Anti inflammatory activity of Mutsangan Ilai Chooranam and Broncho Dilator-Anti-Spasmodic, Anti – Histaminic & Anti-Bacterial Activity of Karpoora Silajith Parpam

    2013

    0 cites

  84. CCDC 727008: Experimental Crystal Structure Determination

    2012

    View DOI
    0 cites

  85. CCDC 805343: Experimental Crystal Structure Determination

    2012

    View DOI
    0 cites

  86. Synthesis, Characterization and Anti-microbial Evaluation of Substituted Benzo[g]indol-2-one Derivatives

    2011

    0 cites

  87. ChemInform Abstract: Synthesis, Antibacterial Activity Evaluation and QSAR Studies of Novel Dispiropyrrolidines.

    2010

    View DOI
    0 cites

  88. ChemInform Abstract: Novel 1,3,5‐Triphenyl‐2‐pyrazolines as Antiinfective Agents.

    2010

    View DOI
    0 cites

  89. Studies on poly Vinylidene fluoride based solid polymer blend electrolytes

    2007

    0 cites

  90. Natural products as anti-inflammatory agents.

    2007

    0 cites

  91. Preparation of Bimetallic Nanoparticles-Catalysts for Polymer Electrolyte Membrane Fuel Cells

    2003

    0 cites

  92. Chemometrics applications and research: QSAR in medicinal chemistry

    Chemometrics Applications and Research: QSAR in Medicinal Chemistry1970book

    0 cites

  93. Potential anti-inflammatory and antiproliferative agents and 1H-isochromen-1-ones and their thio analogues and their QSAR studies

    Chemometrics Applications and Research: QSAR in Medicinal Chemistry1970book chapter

    0 cites

  94. QSAR studies of 1,4-benzodiazepines as CCK<inf>A</inf> antagonist

    Chemometrics Applications and Research: QSAR in Medicinal Chemistry1970book chapter

    0 cites

  95. QSAR studies on dihydrofolate reductase enzyme: From model to biological activity

    Chemometrics Applications and Research: QSAR in Medicinal Chemistry1970book chapter

    0 cites

  96. Materials science of polymers: Plastics, rubber, blends and composites

    Materials Science of Polymers: Plastics, Rubber, Blends and Composites1970book

    View DOI
    0 cites

  97. Photoreactive polymers for microarray chips

    RSC Smart Materials1970book

    0 cites

  98. Biological synthesis of silver nanoparticles and their functional properties

    Nanotechnology: Concepts, Methodologies, Tools, and Applications1970book

    View DOI
    0 cites

  99. Nanostructure, nanosystems, and nanostructured materials: Theory, production, and development

    Nanostructure, Nanosystems, and Nanostructured Materials: Theory, Production and Development1970book

    0 cites

  100. Preface

    Nanostructure, Nanosystems, and Nanostructured Materials: Theory, Production and Development1970book

    0 cites

  101. Artificial neural network model based QSAR for oxygen containing heterocycles as selective COX-2 inhibitors

    Recent Trends on QSAR in the Pharmaeutical Perceptions1970book

    View DOI
    0 cites

  102. Biological synthesis of silver nanoparticles and their functional properties

    Nanoscience and Advancing Computational Methods in Chemistry: Research Progress1970book

    View DOI
    0 cites

  103. Drug utilization of antimicrobials in ENT patients

    Asian Journal of Pharmaceutical and Clinical Research1970journal article

    0 cites

  104. Quantitative structure-cytotoxicity relationships (QSCR) for semi-synthetic Taxoteres against cancer cell lines

    Molecular Simulation1970journal article

    View DOI
    0 cites

  105. Development of odour free anti-microbial hospital linens

    Journal of the Institution of Engineers (India), Part TX: Textile Engineering Division1970journal article

    0 cites

  106. Experimental and theoretical approaches to enhance anti tubercular activity of chalcones

    WSEAS Transactions on Biology and Biomedicine1970journal article

    0 cites

  107. A simple protocol for the miehael addition of indoles with electron deficient olefins catalysed by TBAHS in aqueous media and their broad spectrum antibacterial activity

    Journal of Chemical Sciences1970journal article

    0 cites